NCAM in Neuropsychiatric and Neurodegenerative Disorders

  • Leann H. Brennaman
  • Patricia F. ManessEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)


The neural cell adhesion molecule (NCAM) has roles in normal brain development, including axonal/dendritic growth and branching and synaptic plasticity. A growing body of evidence has implicated NCAM as a susceptible risk for neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, and anxiety disorder, as well as the most prevalent neurodegenerative disease, Alzheimer’s disease. While individuals with these diseases vary in symptoms, age of onset, treatment, and neuronal systems affected, they share cognitive dysfunction as a core feature. This review will highlight the evidence for NCAM in the cause or progression of each of these disorders.


NCAM Schizophrenia Bipolar disorder Depression Anxiety disorder Alzheimer’s disease 



This work was supported by the UNC Schizophrenia Research Center, an NIMH Silvio O. Conte Center for the Neuroscience of Mental Disorders, (NIH grant MH064065 P.F.M.).


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Biochemistry and BiophysicsUniversity of North CarolinaChapel HillUSA
  2. 2.Silvio Conte Center for Schizophrenia ResearchUniversity of North CarolinaChapel HillUSA

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