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Role of NCAM in Emotion and Learning

  • Lisa ConboyEmail author
  • Reto Bisaz
  • Kamila Markram
  • Carmen Sandi
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)

Abstract

NCAM is an abundant cell adhesion molecule known to be important during development. Together with its posttranslational modification consisting of the addition of the polysaccharide polysialic acid (PSA), NCAM has been classically implicated in the regulation - among other developmental functions - of neurite outgrowth and stabilization of synaptic connections. A large body of work has also demonstrated that NCAM is required in the adult brain for different behavioral functions. In this review, we focus on those studies that have shown a role of NCAM and PSA-NCAM in the regulation of emotional responses and in the learning and memory processes.

Keywords

NCAM PSA-NCAM Emotion Learning Memory 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Lisa Conboy
    • 1
    Email author
  • Reto Bisaz
  • Kamila Markram
  • Carmen Sandi
  1. 1.Laboratory of Behavioral GeneticsBrain and Mind Institute, Swiss Federal Institute of Technology (EPFL)LausanneSwitzerland

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