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Biosynthesis of NCAM

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Structure and Function of the Neural Cell Adhesion Molecule NCAM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 663))

Abstract

The neural cell adhesion molecule (NCAM) is abundant in the nervous system. NCAM plays a pivotal role in brain development, synaptic plasticity, and learning and memory processes, as well as regeneration. Alternative splicing of the NCAM single gene gives rise to three major NCAM isoforms termed NCAM-180, NCAM-140, and NCAM-120, named according to their molecular weights. The composition of NCAM isoforms as well as their posttranslational modification change during development. This review summarizes our knowledge on NCAM biosynthesis, focusing on the mechanisms of alternative splicing, biosynthesis, posttranslational modifications, and expression of NCAM in different organs during development.

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Authors and Affiliations

  1. Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Panum Institute, Building 24.2, Blegdamsvej 3C, 2200, Copenhagen, Denmark

    Kateryna Kolkova

  2. Enkam Pharmaceuticals A/S, Fruebjergvej 3, 58, 2100, Copenhagen, Denmark

    Kateryna Kolkova

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  1. Kateryna Kolkova
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Correspondence to Kateryna Kolkova .

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  1. Panum Institute, Dept. Regenerative Medicine, University of Copenhagen, Blegdamsvej 3C, Koebenhavn N, 2200, Denmark

    Vladimir Berezin

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Kolkova, K. (2010). Biosynthesis of NCAM. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_14

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