The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk

  • Gro Klitgaard PovlsenEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)


The neural cell adhesion molecule (NCAM) plays important roles in neuronal development, regeneration, and synaptic plasticity. In vitro, NCAM stimulates neurite outgrowth and neuronal survival and inhibits the proliferation of astrocytes and neuronal progenitors. NCAM exerts these functions by mediating cell-cell and cell-matrix adhesions and by activating intracellular signaling cascades, in which activation of the fibroblast growth factor receptor plays a prominent role. Recent studies in Drosophila suggest that NCAM can also regulate the activity of the Drosophila epidermal growth factor receptor; however, until recently, the putative interaction between NCAM and the epidermal growth factor (EGF) receptor in mammalian cells has not been investigated. Interestingly, the first study addressing this interaction in mammalian cells points to functional crosstalk between NCAM and the EGF receptor in mammals, which differs strikingly from the functional interplay observed between the Drosophila homologs of these molecules.


Neural cell adhesion molecule Epidermal growth factor receptor Neurite outgrowth Drosophila Fasciclin II Receptor downregulation 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.ENKAM PharmaceuticalsCopenhagen ØDenmark

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