Skip to main content

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 202))

Abstract

Pharmaceuticals from a wide spectrum of therapeutic classes are used in human medicine worldwide. Pharmaceutically active compounds are defined as substances used for prevention, diagnosis or treatment of a disease and for restoring, correcting or modifying organic functions (Daughton and Ternes 1999). Pharmaceuticals include more than 4000 molecules with different physico-chemical and biological properties and distinct modes of biochemical action (Beausse 2004). Most medical substances are administrated orally. After administration, some drugs are metabolised, while others remain intact before being excreted. Therefore, a mixture of pharmaceuticals and their metabolites will enter municipal sewage and sewage treatment plants (STP; Kümmerer 2004).

The contents of this article do not necessarily reflect the views and policies of the Department of Pesticide Regulation, nor does mention of trade names or commercial products constitute endorsement or recommendations for use.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • 63 Fed. Reg. 42852 (1998a) Endocrine Disruptor Screening Program. Available at http://www.epa.gov/endo/pubs/081198frnotice.pdf (verified 25 October 2008).

  • 63 Fed. Reg. 71541 (1998b) Endocrine Disruptor Screening Program; Proposed Statement of Policy.

    Google Scholar 

  • 72 Fed. Reg. 33486 (2007) Draft List of Initial Pesticide Active Ingredients and Pesticide Inerts to be Considered for Screening under the Federal Food, Drug, and Cosmetic Act.

    Google Scholar 

  • Atkinson R (1985) Kinetics and mechanisms of the gas-phase reactions of hydroxyl radical with organic compounds under atmospheric conditions. Chem Rev 85:60–201.

    Google Scholar 

  • Baskin LS, Himes K, Colborn T (2001) Hypospadias and endocrine disruption: Is there a connection? Environ Health Perspect 109(11): 1175–1183.

    Article  CAS  Google Scholar 

  • Bidleman TF (1988) Atmospheric Processes: Wet and dry deposition of organic compounds are controlled by their vapor-particle partitioning. Environ Sci Technol 22:361–367.

    Article  CAS  Google Scholar 

  • Burnett G, Thede BM (1995) Summary of environmental fate studies for fenoxycarb, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Laboratory Project Identification ABR-95036, DPR Document No. 51317-0077. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Burton SD (1995) Aerobic aquatic metabolism of 14C-fenoxycarb, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 287-93, DPR Document No. 51317-0077. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • California EPA (2008) Office of Environmental Health Hazard Assessment, Safe Drinking Water and Toxic Enforcement Act of 1986, Chemicals Known To The State To Cause Cancer Or Reproductive Toxicity, September 12, 2008. Sacramento (CA), USA. Available at http://www.oehha.org/Prop65/prop65_list/files/P65single 091208.pdf(verified 23 September 2008).

  • Campiche S, Becker-van Slooten K, Ridreau C, Tarradellas J (2006) Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola). Ecotox Environ Saf 63:216–225.

    Article  CAS  Google Scholar 

  • CCME (Canadian Council of Ministers of the Environment) (2007) Canadian water quality guidelines for the protection of aquatic life: Methoprene. In: Canadian Environmental Quality Guidelines, 1999. Canadian Council of Ministers of the Environment, Winnipeg.

    Google Scholar 

  • CDPR (California Department of Pesticide Regulation) (2006) Summary of Pesticide Use Report Data Indexed By Chemical. California Environmental Protection Agency, Sacramento, CA, p. 171. http://www.cdpr.ca.gov/docs/pur/pur06rep/chmrpt06.pdf

  • Chamberlain WF, Becker JD (1977) Inhibition of cocoon formation and adult emergence of oriental rat fleas, Xenopsylla cheopis (Rothschild), by insect growth regulators. Southwestern Entomol 2:179–182.

    CAS  Google Scholar 

  • Charmillot G, Fabre P (2001) Ovicidal and larvicidal effectiveness of several insect growth inhibitors and regulators on the codling moth Cydia pomonella L. (Lep., Tortricidae). J Appl Entomol 125:147–153.

    Article  CAS  Google Scholar 

  • Clark A (1994) Photodegradation of 14C-fenoxycarb (α-phenyl 14C-CGA-114597) in pH 7 buffered solution under artificial sunlight, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 259-94, DPR Document No. 51317-0080. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Clark A (1995) Photodegradation of 14C-fenoxycarb (β-phenyl 14C-CGA-114597) in pH 7 buffered solution under artificial sunlight, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 283-93, DPR Document No. 51317-0079. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Crisp TM, Clegg ED, Cooper RL, Wood WP, Anderson DG, Baetcke KP, Hoffmann JL, Morrow MS, Rodier DJ, Schaeffer JE, Touart LW, Zeeman MG, Patel YM (1998) Environmental endocrine disruption: An effects assessment and analysis. Environ Health Perspect 106(Suppl 1):11–56.

    Article  CAS  Google Scholar 

  • Dhadialla TS, Carlson GR, Le DP (1998) New insecticides with ecdysteroidal and juvenile hormone activity. Ann Rev Entomol 43:545–569.

    Article  CAS  Google Scholar 

  • Dixon B (1995) Aerobic and aerobic/anaerobic metabolism of “A” label 14C-Fenoxycarb in a sandy loam soil, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 76-94, DPR Document No. 51317-0082. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Eisa AA, El-Fatah MA, El-Nabawi A, El-Dash AA (1991) Inhibitory effects of some insect growth regulators on developmental stages, fecundity and fertility of the Florida Wax Scale, Ceroplastes floridensis. Phytoparasitica. 19:49.

    Article  CAS  Google Scholar 

  • Eliahu M, Blumberg D, Horowitz AR, Ishaaya I (2007) Effect of pyriproxyfen on developing stages and embryogenesis of California red scale (CRS), Aonidiella aurantii. Pest Manag Sci 63:743–746.

    Article  CAS  Google Scholar 

  • Ellgehausen H (1985) Accumulation and elimination of 14C-RO 13-5223/024 by bluegill sunfish in a dynamic flow through system, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 034841, DPR Document No. 51317-0086. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Environment Canada (1998) Federal Ministers Announce that $40 million will be allocated to research on health and environment in Canada. Communiqué, 7 December 1998.

    Google Scholar 

  • EPI Suite (Estimation Programs Interface Suite) (2004) U.S. EPA Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC), v. 2.20 (Feb. 2007) Available at http://www.epa.gov/oppt/exposure/pubs/episuite.htm (verified 20 November 2008).

  • Evans RG, Sunley A, Bradford C, Patmore RI (1995) Effects of fenoxycarb on development and reproduction of the oriental cockroach, Blatta orientalis. Med Vet Entomol 9(3):235–240.

    Article  CAS  Google Scholar 

  • FQPA (Food Quality Protection Act of 1996) (1996) Available at http://www.epa.gov/pesticides/regulating/laws/fqpa/ (verified 25 October 2008).

  • Garry VV (2004) Pesticides and children. Toxicol Appl Pharmacol 198(2): 152–163.

    Article  CAS  Google Scholar 

  • Girard J (2005) Principles of environmental chemistry. Jones & Bartlett Publishers, Sudbury, MA, p. 494.

    Google Scholar 

  • Godfrey CRA (1995) Agrochemicals from natural products. Marcel Dekker, Inc., New York, NY, p. 161.

    Google Scholar 

  • Grenier S, Grenier AM (1993) Fenoxycarb, a fairly new insect growth regulator: a review of its effects on insects. Ann Appl Biol 122:369–403.

    Article  CAS  Google Scholar 

  • Hajek A (2004) Natural enemies: An introduction to biological control. Cambridge University Press, UK, p. 327.

    Google Scholar 

  • Hosmer AJ, Warren LW, Ward TJ (1998) Chronic toxicity of pulse-dosed fenoxycarb to daphnia magna exposed to environmentally realistic concentrations. Environ Toxicol Chem 17:1860–1866.

    CAS  Google Scholar 

  • Lee BM, Scott GI (1989) Acute toxicity of temephos, fenoxycarb, diflubenzuron, and methoprene and Bacillus thuringiensis var. israelensis to the mummichog (Fundulus heteroclitus). Bull Environ Contam Toxicol 43(6):827–832.

    Article  CAS  Google Scholar 

  • Maddison JE, Page SW, Church D (2008) Small animal clinical pharmacology, 2nd ed. Elsevier Health Sciences, New York, NY, p. 187.

    Google Scholar 

  • Mamatha DM, Kanji VK, Cohly HHP, Rao MR (2008) Juvenile hormone analogues, methoprene and fenoxycarb dose-dependently enhance certain enzyme activities in the silkworm Bombyx Mori (L). Int J Environ Res Pub Health 5(2):120–124.

    CAS  Google Scholar 

  • Marchiondo AA, Riner JL, Sonenshine DE, Rowe KF Slusser JH (1990) Ovicidal and larvicidal modes of action of fenoxycarb against the cat flea (Siphonaptera: Pulicidae). J Med Entomol 27(5):913–921.

    CAS  Google Scholar 

  • Masner P, Angst M, Dorn S (1987) Fenoxycarb, an insect growth regulator with juvenile hormone activity: A candidate for Heliothis virescens (F.) control on cotton. Pest Sci 18: 89–94.

    Article  CAS  Google Scholar 

  • Mather V, Bhatnagar P, Sharma RG, Acharya V, Sexana R (2002) Breast cancer incidence and exposure to pesticides among women originating from Jaipur. Environ Int 28(5): 331–336.

    Article  Google Scholar 

  • McDonald J (1995) Terrestrial Dissipation of 14C-Fenoxycarb 25 WP on bare ground soil in California, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 279-94, DPR Document No. 51317-0092. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • McKenney CL Jr., Gripe GM, Foss SS, Tuberty SR, Hoglund M (2004) Comparative embryonic and larval developmental responses of an estuarine shrimp (Palaemonetes pugio) to the juvenile hormone agonist, fenoxycarb. Arch Environ Contam Toxicol 47:463–470.

    Article  CAS  Google Scholar 

  • McKinlay R, Plant JA, Bell JNB, Voulvoulis N (2008) Endocrine disrupting pesticides: Implications for risk assessment. Environ Int 34:168–183.

    Article  CAS  Google Scholar 

  • Miyamoto J, Hirano M, Takimoto Y, Hatakoshi M (1993) Insect growth regulators for pest control with emphasis on juvenile hormone analogue: Present status and future prospects. Pest Cont Enhance Environ Saf 524: 144–168.

    Article  CAS  Google Scholar 

  • Nates SF, McKenney CL Jr. (2000) Growth, lipid class and fatty acid composition in juvenile mud crabs (Rhithropanopeus harrisii) following larval exposure to fenoxycarb, insect juvenile hormone agonist. Comp Biochem Physiol C Toxicol Pharmacol 127:317–325.

    CAS  Google Scholar 

  • OECD (2007) Organisation for Economic Co-operation and Development: Draft updated test guideline 407. Available at http://www.oecd.org/dataoecd/22/27/39791889.pdf (verified 25 October 2008).

  • Pryde A, Von der Muhll A (1985) Nature of radioactive residues in 14C-RO 13-5223/024-treated bluegill sunfish, Dr. R. Maag AG (Syngenta Crop Protection, Inc), Maag Project No. 041/5369, DPR Document No. 51317-0086. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Rajapakse CNK, Meola R, Readio J (2002) Comparative evaluation of juvenoids for control of cat fleas (Siphonaptera: Pulicidae) in topsoil. J Med Entomol 39:889–894.

    Article  Google Scholar 

  • Reid BL, Bennett GW, Yonker JW (1990) Influence of fenoxycarb on German cockroach (Dictyoptera: Blattellidae) populations in public housing. J Econ Entomol 83(2):444–450.

    CAS  Google Scholar 

  • Rice F, Fieser J, Speth RM (1995) Terrestrial dissipation of fenoxycarb 25 WP on bare ground in Washington, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 188-93, DPR Document No. 51317-0093. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Riddiford LM (1994) Cellular and molecular actions of juvenile hormone I. General considerations and premetamorphic actions. Adv Insect Physiol 24:213–274.

    Article  CAS  Google Scholar 

  • Schaefer CH, Wilder WH, Mulligan FS, and Dupras EE (1987) Efficacy of fenoxycarb against mosquitoes (Diptera: Culicidae) and its persistence in the laboratory and field. J Econ Entomol 80(1): 126–130.

    CAS  Google Scholar 

  • Schreinemachers DD (2003) Birth malformations and other adverse perinatal outcomes in four U.S. wheat producing states. Environ Health Perspect 111(9):1259–1264.

    Article  CAS  Google Scholar 

  • Schwartz B (1995) Aerobic and anaerobic metabolism of 14C-fenoxycarb in a sandy loam soil, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 228-92, DPR Document No. 51317-0083. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • SDWA (1996) Safe Drinking Water Act. Available at http://www.epa.gov/safewater/sdwa/ (verified 25 October 2008).

  • Shepler K (1995) Column leaching of 14C-CGA-294847 in five soil types, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Project No. 504 W, DPR Document No. 51317-0086. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Shuster LL, Goff KE (1995) Dissipation of Fenoxycarb in Soil under field conditions with and without crop (squash) in California, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 181-93, DPR Document No. 51317-0090. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Sláma, K (1999) The history and current status of juvenoids. In: WH Robinson, F. Rettich and GW Rambo (eds.) Proceedings of the 3rd International Conference on Urban Pests, pp 9–24.

    Google Scholar 

  • Spare WC (1995a) The adsorption and desorption of 14C-fenoxycarb by the batch equilibrium method on representative agricultural soils, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 12213, DPR Document No. 51317-0088. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Spare WC (1995b) The adsorption and desorption of 14C-CGA-294847 by the batch equilibrium method on representative agricultural soils, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 12214, DPR Document No. 51317-0087. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Sparrow K (1995) Photodegradation of 14C-fenoxycarb on soil under artificial sunlight, Ciby-Geigy Crop Protection (Syngenta Crop Protection, Inc), Study No. 250-94, DPR Document No. 51317-0081. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Tasei JN (2001) Effects of insect growth regulators on honey bees and non-Apis bees. A review. Apidologie 32:527–545.

    Article  CAS  Google Scholar 

  • Tatarazako N, Oda S, Watanabe H, Morita M, Iguchi T (2003) Juvenile hormone agonists affect the occurrence of male Daphnia. Chemosphere 53:827–833.

    Article  CAS  Google Scholar 

  • Templeton NS, Laufer H (1983) The effects of a juvenile hormone analogue (Altosid ZR-515) on the reproduction and development of Daphnla magna (Crustacea: Cladocera). Int J Invert Reprod 6:99–110.

    CAS  Google Scholar 

  • Testing Advisory Committee (EDSTAC), final report (1998). Available at http://www.epa.gov/endo/pubs/edstac/exesum14.pdf (verified 25 October 2008).

  • Thomas B (1994) Hydrolysis of 14C-Fenoxycarb at pH 5, 7, and 9 Ciba-Geigy Corporation (Syngenta Crop Protection), Ciba Study No. 348-92, DPR Document No. 51317-0078. This unpublished study is proprietary data cited with the authorization of Syngenta Crop Protection, Inc.

    Google Scholar 

  • Tomlin C (2006) The pesticide manual, 14th ed. BCPC Publications, Berkshire, UK, pp 923–924.

    Google Scholar 

  • U.S. EPA (1998) U.S. Environmental Protection Agency. Endocrine Disruptor Screening Testing Advisory Committee (EDSTAC), final report (1998). Available at http://www.epa.gov/endo/pubs/edstac/exesum14.pdf (verified 25 October 2008).

  • U.S. EPA (2000) Pesticide ecotoxicity database. Office of Pesticide Programs, Environmental Fate and Effects Division, U.S. EPA, Washington, DC.

    Google Scholar 

  • U.S. EPA (2007) June 2007 Draft List of Chemicals for Initial Tier 1 Screening. Available at http://www.epa.gov/endo/pubs/prioritysetting/draftlist.htm (verified 25 October 2008).

  • U.S. EPA Office of Pesticide Programs (2007) Chemicals evaluated for carcinogenic potential. Available at http://www.epa.gov/pesticides/carlist/(verified 25 October 2008).

  • UC Statewide IPM Program. (Feb. 2007) Pest Notes: Ants. Oakland: Univ. Calif. Agric. Nat. Res. Publ. 7411.

    Google Scholar 

  • Unger TA (1996) Pesticide synthesis handbook. William Andrew, Inc. Norwish, NY, p. 82.

    Book  Google Scholar 

  • Verslycke TA, Fockedey N, McKenney CL Jr., Roast SD, Jones MB, Mees J, Janssen CR (2004) Mysids crustaceans as potential test organisms for the evaluation of environmental endocrine disruption: A review. Environ Toxicol Chem 23:1219–1234.

    Article  CAS  Google Scholar 

  • WHO (2006) Pesticides and their application for the control of vectors and pests of public health importance, 6th ed. World Health Organization, Geneva. Available at http://whqlibdoc.who.int/hq/2006/WHO_CDS_NTD_WHOPES_GCDPP_2006.1_eng.pdf

  • WHO/IPCS (World Health Organization/International Petroleum Chemical Society) (2002) Global Assessment of the State-of-the-Science of Endocrine Disruptors. Damstra T, Barlow S, Bergman A, Kavlock R, Van Der Kraak G (eds) WHO/IPCS/EDC/02.2 World Health Organization, Geneva, Switzerland, http://ehp.niehs.nih.gov/who/ (verified 23 September 2008).

  • Zala S, Penn DJ (2004) Abnormal behaviors induced by chemical pollution: A review of the evidence and new challenges. Anim Behav 68:649–664.

    Article  Google Scholar 

  • Zhou X, Riddiford LM (2002) Broad specifies pupal development and mediates the ‘status quo’ action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. Development 129:2259–2269.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan J. Sullivan .

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Sullivan, J.J. (2010). Chemistry and Environmental Fate of Fenoxycarb. In: Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 202. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1157-5_3

Download citation

Publish with us

Policies and ethics