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Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 202))

Abstract

Perfluorinated compounds (PFCs) are fluorinated at all of the valence electrons of the carbon atoms in organic molecules, or at least a portion of the molecule is perfluorinated (Fig. 1). All PFCs are synthetic and many have been used in commercially available products or released as byproducts. A partial list of the compounds that are known to have been manufactured and/or released into the environment is given in Table 1. These compounds vary in structure, and thus exhibit different environmental fates and toxicities. Unfortunately, there is presently little information on the chemical–physical properties of most PFCs, and even less toxicity information is available on these compounds.

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References

  • 3 M (2003) Environmental and health assessment of perfluorooctane sulfonic acid and its salts. Prepared by 3 M Company with J. Moore (Holly house Inc., J. Rodricks and D. Turnbull (Environ Corp) and W. Warren Hicks (Cadmus Group). August 2003.

    Google Scholar 

  • Ankley GT, Niemi, GJ, Lodge KB, Harris HJ, Beaver DL, Tillitt DE, Schwartz T, Giesy JP, Jones PD, Hagley C (1993) Uptake of planar polychlorinated biphenyls and 2,3,7, 8-substituted polychlorinated dibenzofurans and dibenzo-p-dioxins by birds nesting in the lower Fox River and Green Bay, Wisconsin, USA. Arch Environ Contam Toxicol 24:332–344.

    Article  CAS  Google Scholar 

  • Ankley GT, Kuehl DW, Kahl MD, Jensen KM, Butterworth BC, Nichols JW (2004) Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens). Environ Toxicol Chem 23:2745–2755.

    Article  CAS  Google Scholar 

  • Barron MG, Hansen JA, Lipton J (2002) Association between contaminant tissue residues and effects in aquatic organisms. Rev Environ Contam Toxicol 173:1–37.

    Google Scholar 

  • Boudreau T, Sibley P, Mabury SA, Muir DCG, Solomon KR (2002) Toxicity of perfluoroalkyl carboxylic acids of different chain lengths to selected freshwater organisms. Department of Environmental Biology, Masters Thesis, University of Guelph, ON, p. 134.

    Google Scholar 

  • Boudreau TM, Sibley PK, Mabury SA, Muir DCG, Solomon KR (2003a) Laboratory evaluation of the toxicity of perfluorooctane sulfonate (PFOS) on Selenastrum capricornutum, Chlorella vulgaris, Lemna gibba, Daphnia magna, and Daphnia pulicaria.Arch Environ Contam Toxicol 44:307–313.

    Article  CAS  Google Scholar 

  • Boudreau TM, Wilson CJ, Cheong WJ, Sibley PK, Mabury SA, Muir DCG, Solomon KR (2003b) Response of the zooplankton community and environmental fate of perfluorooctane sulfonic acid in aquatic microcosms. Environ Toxicol Chem 22:2739–2745.

    Article  CAS  Google Scholar 

  • Bowerman WW, Best DA, Grubb TG, Zimmerman M, Giesy JP (1998) Trends of contaminants and effects in bald eagles of the Great Lakes Basin. Environ Monitor Assess 53:197–212.

    Article  CAS  Google Scholar 

  • CCME (1999) A protocol for the derivation of water quality guidelines for the protection of aquatic life. Canadian Environmental Quality Guideline. Canadian Council of Ministers of the Environment, Ottawa.

    Google Scholar 

  • Chapman PM, Fairbrother A, Brown D (1998) Critical evaluation of safety (uncertainty) factors for ecological risk assessment. Environ Toxicol Chem 17:99–108.

    Article  CAS  Google Scholar 

  • Condor JM, Hoke RA, De Wolf W, Russell MH, Buck RC (2008) Are PFCAs bioaccumulative? A critical review and comparison with regulatory criteria and persistent lipophilic compounds. Environ Sci Technol 42:995–1003.

    Article  Google Scholar 

  • Desjardins D, Sutherland CA, VanHoven RL, Krueger HO (2001a) PFOS: A 96-hr toxicity test with the freshwater alga (Anabaena flos-aquae). Wildlife International, Ltd., Project Number 454A-110B, EPA Docket AR226-0186.

    Google Scholar 

  • Desjardins D, Sutherland CA, VanHoven RL, Krueger HO (2001b) PFOS: A 96-hr toxicity test with the marine diatom (Skeletonema costatum). Wildlife International, Ltd., Project Number 454A-113A, EPA Docket AR226-1030a056.

    Google Scholar 

  • Desjardins D, Sutherland C, VanHoven RL, Krueger HO (2001c) PFOS: A 7-d toxicity test with duckweed (Lemna gibba G3). Wildlife International, Ltd. Project Number 454-111, EPA Docket AR226-1030a054.

    Google Scholar 

  • Di Toro DM, McGarth JA, Hansen DJ (2000) Technical basis for narcotic chemicals and polycyclic aromatic hydrocarbon criteria. I. Water and tissue. Environ Toxicol Chem 19:1951–1970.

    Article  Google Scholar 

  • Dixon DA (2001) Fluorochemical decomposition process. Theory, modeling, and simulation. WR Wiley Environmental Molecular Sciences Lab., Pacific Northwest National Lab., Richmond, WA.

    Google Scholar 

  • Drottar KR, Krueger HO (2000a) PFOS: A 96-hr toxicity test with the freshwater alga (Selenastrum capricornutum). Wildlife International, Ltd., Project Number 454A-103A, EPA Docket AR226-0085.

    Google Scholar 

  • Drottar KR, Krueger HO (2000b) PFOS: A 48-hr static acute toxicity test with the cladoceran (Daphnia magna). Wildlife International, Ltd., Project No. 454A-104, EPA Docket AR226-0087.

    Google Scholar 

  • Drottar KR, Krueger HO (2000c) PFOS: A 96-hr static acute toxicity test with the freshwater mussel (Unio complanatus). Wildlife International, Ltd., Project No. 454A-105, EPA Docket AR226-0091.

    Google Scholar 

  • Drottar KR, Krueger HO (2000d) PFOS: A 96-hr static acute toxicity test with the saltwater mysid (Mysidopsis bahia). Wildlife International, Ltd. Project No. 454A-101, EPA Docket AR226-0095.

    Google Scholar 

  • Drottar KR, Krueger HO (2000e) PFOS: A 96-hr shell deposition test with the eastern oyster (Crassostrea virginica). Wildlife International, Ltd., Project No. 454A-106, EPA Docket AR226-0089.

    Google Scholar 

  • Drottar KR, Krueger HO (2000f) PFOS: A semi-static life-cycle toxicity test with the cladoceran (Daphnia magna). Wildlife International Ltd., Project No. 454A-109, EPA Docket AR226-0099.

    Google Scholar 

  • Drottar KR, Krueger HO (2000 g) PFOS: A flow through life-cycle toxicity test with the saltwater mysid (Mysidopsis bahia). Wildlife International, Ltd., Project No. 454A-107, EPA Docket AR226-0101.

    Google Scholar 

  • Drottar KR, Krueger HO (2000 h) PFOS: A 96-hr static acute toxicity test with the fathead minnow (Pimephales promelas). Wildlife International, Ltd., Project No. 454-102, EPA Docket AR226-0083.

    Google Scholar 

  • Drottar KR, Krueger HO (2000i) PFOS: An early life-stage toxicity test with the fathead minnow (Pimephales promelas). Wildlife International, Ltd., Project No. 454-108, EPA Docket AR226-0097.

    Google Scholar 

  • Drottar KR, VanHoven RL, Krueger HO (2001) Perfluorooctanesulfonate, potassium salt (PFOS): A flow-through bioconcentration test with the bluegill (Lepomis macrochirus). Wildlife International, Ltd., Project No. 454A-134, EPA Docket AR226-1030a042.

    Google Scholar 

  • Ellefson M (2001a) Solubility of PFOS in natural seawater and an aqueous solution of 3.5% of sodium chloride. 3 M Company, 3 M Environmental Laboratory, Laboratory Project No. E00-1716, EPA Docket AR226-1030a026.

    Google Scholar 

  • Ellefson M (2001b) Solubility of PFOS in octanol. 3 M Company, 3 M Environmental Laboratory, Laboratory Project No. E00-1716, EPA Docket AR226-1030a027.

    Google Scholar 

  • Ellefson M (2001c) Solubility of PFOS in water. 3 M Company, 3 M Environmental Laboratory, Laboratory Project No. E00-1716, EPA Docket AR226-1030a025.

    Google Scholar 

  • Ellefson M (2001d) Soil adsorption/desorption study of potassium perfluorooctanesulfonate (PFOS). 3 M Company, 3 M Environmental Laboratory, Laboratory Project No. E00-1311, EPA Docket AR226-1030a030.

    Google Scholar 

  • Fisk AT, Norstrom RJ, Cymbalisty CD, Muir DCG (1998) Dietary accumulation and depuration of hydrophobic organochlorines: Bioaccumulation parameters and their relationship with the octanol/water partition coefficient. Environ Toxicol Chem 17:951–961.

    Article  CAS  Google Scholar 

  • Giesy JP, Ludwig JP, Tillitt DE (1994) Dioxins, dibenzofurans, PCBs and colonial fish-eating water birds. In: Schecter A (ed) Dioxin and health. New York, NY, Plenum Press, pp. 249–307.

    Google Scholar 

  • Giesy JP, Kannan K (1998) Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): Implications for risk assessment. Crit Rev Toxicol 28:511–569.

    Article  CAS  Google Scholar 

  • Giesy JP, Kannan K (2001) Global distribution of perfluorooctane sulfonate in wildlife. Environ Sci Technol 35:1339–1342.

    Article  CAS  Google Scholar 

  • Giesy JP, Kannan K (2002) Perfluorochemical surfactants in the environment. Environ Sci Technol 36:146A–152A.

    Article  CAS  Google Scholar 

  • Giesy JP, Newsted JL (2001) Selected fluorochemicals in the Decatur Alabama Area. 3 M Report, Project No. 178041. EPA Docket AR226-1030a161.

    Google Scholar 

  • Gledhill WE, Markley BJ (2000a) Microbial metabolism (biodegradation) studies of perfluorooctane sulfonate (PFOS). I. Activated sludge/sediment. Springborn Laboratories, Inc., Wareham, MA. Lab ID Number 290.6120, EPA Docket AR226-1030a034.

    Google Scholar 

  • Gledhill WE, Markley BJ (2000b) Microbial metabolism (biodegradation) studies of perfluorooctane sulfonate (PFOS). II. Aerobic soil biodegradation. Springborn Laboratories, Inc., Wareham, MA. Lab ID Number 290.6120, EPA Docket AR226-1030a035.

    Google Scholar 

  • Gledhill WE, Markley BJ (2000c) Microbial metabolism (biodegradation) studies of perfluorooctane sulfonate (PFOS). III. Anaerobic sludge biodegradation. Springborn Laboratories, Inc., Wareham, MA. Lab ID Number 290.6120, EPA Docket AR226-1030a036.

    Google Scholar 

  • Goecke-Flora CM, Reo NV (1996) Influence of carbon chain length on the hepatic effects of perfluorinated fatty acids. Chem Res Toxicol 9:689–695.

    Article  CAS  Google Scholar 

  • Hanson ML, Sibley PK, Brain RA, Mabury SA, Solomon R (2005) Microcosm evaluation of the toxicity and risk to aquatic macrophytes from perfluorooctane sulfonic acid. Arch Environ Contam Toxicol 48:329–337.

    Article  CAS  Google Scholar 

  • Hatfield T (2001a) Screening studies on the aqueous photolytic degradation of potassium perfluorooctane sulfonate (PFOS). 3 M Environmental Laboratory, Lab Request No. W2775, St. Paul, MN, EPA Docket AR226-1030a041.

    Google Scholar 

  • Hatfield T (2001b) Hydrolysis reactions of perfluorooctane SULFONATE (PFOS). 3 M Environmental Laboratory, Lab Request No. W1878. St. Paul, MN, EPA Docket AR226-1030a039.

    Google Scholar 

  • Hekster FM, Laane RWPM, de Voogt P (2003) Environmental and toxicity effects of perfluoroalkylated substances. Rev Environ Contam Toxicol 179:99–121.

    Article  CAS  Google Scholar 

  • Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP (2002) Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68:429–439.

    Article  CAS  Google Scholar 

  • Jacobs RL, Nixon WB (1999) Determination of the melting point/melting range of PFOS. Wildlife International, Ltd., Project No. 454C-106. EPA Docket AR226-0045.

    Google Scholar 

  • Johnson JD, Gibson SJ, Ober RE (1984) Cholestyramine-enhanced fecal elimination of carbon-14 in rats after administration of ammonium [14-C] perfluorooctanoate and potassium [14-C] perfluorooctane sulfonate. Fund Applied Toxicol 4:972–976.

    Article  CAS  Google Scholar 

  • Jones PD, Hu W, DeCoen W, Newsted JL, Giesy JP (2003) Binding of perfluorinated fatty acids to serum protein. Environ Toxicol Chem 22:2639–2649.

    Article  CAS  Google Scholar 

  • Kannan K, Tao L, Sinclair E, Paskva S, Jude DL, Giesy JP (2005) Perfluorinated compounds in aquatic organisms at various levels in a Great Lakes food chain. Arch Environ Contam Toxicol 48:559–566.

    Article  CAS  Google Scholar 

  • Kannan K, Franson JC, Bowerman WW, Hansen KJ, Jones PD, Giesy JP (2001b) Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses. Environ Sci Technol 35: 3065–3070.

    Article  CAS  Google Scholar 

  • Kannan K, Koistinen J, Beckmen K, Evans T, Gorzelany JF, Hansen KJ, Jones PD, Helle E, Nyman M, Giesy JP (2001a) Accumulation of perfluorooctane sulfonate in marine mammals. Environ Sci Technol 35:1593–1598.

    Article  CAS  Google Scholar 

  • Kleszczynski K, Gardzielewski P, Mulkiewicz E, Stepnowski P, Skladanowski AC (2007) Analysis of structure-cytotoxicity in vitro relationships (SAR) for perfluorinated carboxylic acids. Toxicol In Vitro 21:1206–1211.

    Article  CAS  Google Scholar 

  • Kurume Laboratory (2001) Final report, Bioconcentration test of 2-perfluoroalkyl (C=4-14) ethanol [This test was performed using 2-(perfluorooctyl)-ethanol (Test substance number K-1518)] in carp. Kurume Laboratory, Chemicals Evaluation and Research Institute, Japan. EPA Docket AR226-1276.

    Google Scholar 

  • Kurume Laboratory (2002) Final report, Biodegradation test of salt (Na, K, Li) of perfluoroalkyl (C=4-12) sulfonic acid, test substance number K-1520 (test number 21520). Kurume Laboratory, Chemicals Evaluation and Research Institute, Japan.

    Google Scholar 

  • Lange CC (2001) The 35-d aerobic biodegradation study of PFOS. Pace Analytical Services, Minneapolis, MN. 3 M Project Number E01-0444. EPA Docket AR226-1030a040.

    Google Scholar 

  • Langely AE (1990) Effects of perfluoro-n-decanoic acid on respiratory activity of isolated rat liver mitochondria. J Toxicol Environ Health 29:329–336.

    Article  Google Scholar 

  • Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicol Sci 99:366–394.

    Article  CAS  Google Scholar 

  • Leonards PEG, Zierikzee Y, Brinkman UATh, Cofino WP, van Straalen NM, van Hattum B (1997) The selective dietary accumulation of planar polychlorinated biphenyls in the otter (Lutra lutra). Environ Toxicol Chem 16:1807–1815.

    CAS  Google Scholar 

  • MacDonald MM, Warne AL, Stock NL, Mabury SA, Solomon KR, Sibley PK (2004) Toxicity of perfluorooctane sulfonic acid and perfluorooctanoate to Chironomus tentans. Environ Toxicol Chem 23:2116–2123.

    Article  CAS  Google Scholar 

  • Martin JW, Mabury SA, O'Brian PJ (2005) Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes. Chem Biol Interact 155:165–180.

    Article  CAS  Google Scholar 

  • Martin JW, Mabury SA, Solomon KR, Muir DCG (2003a) Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem 22:189–195.

    CAS  Google Scholar 

  • Martin JW, Mabury SA, Solomon K, Muir DCG (2003b) Bioconcentration and tissue distribution of perfluorinated acids in rainbow (Oncorhynchus mykiss). Environ Toxicol Chem 22:196–204.

    CAS  Google Scholar 

  • McCarty LS, Mackay D (1993) Enhancing ecotoxicological modeling and assessment. Environ Sci Technol 27:1719–1728.

    Article  Google Scholar 

  • Moody CA, Martin JW, Kwan WC, Muir DCG, Mabury SA (2001) Monitoring perfluorinated surfactants in biota and surface water samples following an accidental release of fire-fighting foam into Etobicoke Creek. Environ Sci Technol 36:545–551.

    Article  Google Scholar 

  • Mulkiewicz E, Jastorff B, Skladanowski AC, Kleszczynski K, Stepnowski P (2007) Evaluation of the acute toxicity of perfluorinated carboxylic acids using eukaryotic cell lines, bacteria and enzymatic assays. Environ Toxicol Pharmacol 23:279–285.

    Article  CAS  Google Scholar 

  • Newsted JL, Beach SA, Gallagher SP, Giesy JP (2008) Acute and chronic effects of perfluorobutane sulfonate (PFBS) on the mallard and northern bobwhite quail. Arch Environ Contam Toxicol 54:535–545.

    Article  CAS  Google Scholar 

  • Newsted JL, Coady KK, Beach SA, Butenhoff JL, Gallagher S, Giesy JP (2007) Effects of perfluorooctane sulfonate on mallard and northern bobwhite quail exposed chronically via the diet. Environ Toxicol Pharmacol 23:1–9.

    Article  CAS  Google Scholar 

  • NICNAS (2005) Potassium perfluorobutane sulfonate. Report to the National Industrial Chemicals Notification and Assessment Scheme, Sydney Australia.

    Google Scholar 

  • Oakes KD, Sibley PK, Martin JW, MacLean DD, Solomon KR, Mabury SA, Van Der Kraak GJ (2005) Short-term exposures of fish to perfluorooctane sulfonate: Acute effects on fatty acyl-CoA oxidase activity, oxidative stress, and circulating sex steroids. Environ Contam Toxicol 24:1172–1181.

    CAS  Google Scholar 

  • Obourn J, Frame SR, Bell RH, Longnecker DS, Elliott GS, Cook J (1997) Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator wyeth-14,643.Toxicol Appl Pharmacol 145:425–436.

    Article  CAS  Google Scholar 

  • OECD (Organization for Economic Cooperation and Development) (2002) Hazard assessment of perfluorooctane sulfonate (PFOS) and its salts. ENV/JM/RD 17/Final. 21 November, 2002. Paris, p. 362.

    Google Scholar 

  • Ohmori K, Kudo N, Katayama K, Kawashima Y (2006) Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length. Toxicol 184:135–140.

    Article  Google Scholar 

  • Olson CT, Anderson ME (1983) The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids. Toxicol Appl Pharmacol 70:362–372.

    Article  CAS  Google Scholar 

  • Palmer SJ, Krueger HO (2001) PFOS: A frog embryo teratogenesis assay-Xenopus(FETAX). Wildlife International, Ltd., Project No. 454A-116. EPA Docket AR226-1030a057.

    Google Scholar 

  • Palmer SJ, Van Hoven RL, Krueger HO (2002a) Perfluorooctanesulfonate, potassium salt (PFOS): A 96-hr static acute toxicity test with the rainbow trout (Oncorhynchus mykiss). Wildlife International Ltd. Report No. 454A-145. EPA Docket AR226-1030a044.

    Google Scholar 

  • Palmer SJ, van Hoven RL, Krueger HO (2002b) Perfluorooctanesulfonate, potassium salt (PFOS): A 96-hr static renewal acute toxicity test with the sheepshead minnow (Cyprinodon variegatus). Wildlife International Ltd. Report No. 454A-146A.

    Google Scholar 

  • Phillips MM, Dinglasan-Panlilio MJA, Mabury SA, Solomon KR, Sibley PK (2007) Fluorotelomer acids are more toxic than perfluorinated acids. Environ Sci Technol 41:7159–7163.

    Article  Google Scholar 

  • RIVM (2001) Guidance document on deriving environmental risk limits in the Netherlands. In: Traas TP (ed) Report No. 601501 012. National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

    Google Scholar 

  • Robertson JC (1986) Potential for environmental impact of AFA-6 surfactant. Beak Consultants Ltd. Missassauga, Ontario, Canada. EPA Docket AR226-1030a043.

    Google Scholar 

  • Sargent J, Seffl R (1970) Properties of perfluorinated liquids. Fed Proc 29:1699–1703.

    CAS  Google Scholar 

  • Schaefer EL, Flaggs RS (2000) PFOS: An activated sludge respiration inhibition test. Wildlife International, Ltd., Project No. 454E-101, EPA Docket AR226-0093.

    Google Scholar 

  • Schnellmann RG, Manning RO (1990) Perfluorooctane sulfonamide: A structurally novel uncoupler of oxidative phosphorylation. Biochem Biophys Acta 1016:344–348.

    Article  CAS  Google Scholar 

  • Sohlenius AK, Andersson K, Bergstrand A, Spydevold O, De Pierre JW (1994) Effects of perfluorooctanoate, a potent peroxisome proliferator in rat, on morris hepatoma 7800C1 cells, a rat cell line. Biochem Biophys 1213:63–74.

    CAS  Google Scholar 

  • Starkov A, Wallace KB (2002) Structural determinants of fluorochemicals-induced mitochondrial dysfunction. Toxicol Sci 66:244–252.

    Article  CAS  Google Scholar 

  • Sutherland CA, Krueger HO (2001) PFOS: A 96-hr toxicity test with the freshwater diatom (Navicula pelliculosa). Wildlife International, Ltd., Project Number 454A-112. EPA Docket AR226-1030a055.

    Google Scholar 

  • Taniyasu S, Kannan K, Horii Y, Hanari N, Yamashita N (2003) A survey of perfluorooctane sulfonate and related perfluorinated organic compounds in water, fish, birds, and humans from Japan. Environ Sci Technol 37:2634–2639.

    Article  CAS  Google Scholar 

  • Tolls J, Haller M, Graaf ID, Thijssen MATC, Sijm DTHM (1997) Bioconcentration of LAS: Experimental determination and extrapolation to environmental mixtures. Environ Sci Technol 31:3426–3431.

    Article  CAS  Google Scholar 

  • Tolls J, Sijm DJHM (1995) A preliminary evaluation of the relationship between bioconcentration and hydrophobicity for surfactants. Environ Toxicol Chem 14:1675–1685.

    Article  CAS  Google Scholar 

  • Trosko JE, Rush RJ (1998) Epigenetic toxicology as toxicant-induced changes in signaling leading to altered gap junctional intercellular communication. Toxicol Lett 102/103:71–78.

    Article  Google Scholar 

  • Upham BL, Deocampo ND, Wurl B,Trosko JE (1998) Inhibition of gap junctional intercellular communication by perfluorinated fatty acids is dependent on the chain length of the fluorinated tail. Int J Cancer 78:491–495.

    Article  CAS  Google Scholar 

  • US EPA (1985) Guidelines for deriving numerical national water quality criteria for the protection of aquatic organisms and their uses. PB-85-227049. US Environmental Protection Agency, NTIS, Springfield, VA, USA.

    Google Scholar 

  • US EPA (1995) Final Water Quality Guidance for the Great Lakes System: Final Rule. Federal Register 60: 15366-15425. US EPA, Washington, DC, USA.

    Google Scholar 

  • US EPA (2001) Perfluorooctyl sulfonates; proposed significant new use rule. Federal Register 65:62319–62333.

    Google Scholar 

  • Van Hoven RL, Stenzel JI, Nixon WB (1999) Determination of the vapor pressure of PFOS using the spinning rotor gauge method. Wildlife International, Ltd., Project Number 454C-105. EPA Docket AR226-0048.

    Google Scholar 

  • Wildlife International Ltd (2001a) PFBS: An activated sludge respiration test. Wildlife International Ltd., Project No. 454E-102A.

    Google Scholar 

  • Wildlife International Ltd. (2001b) Perfluorobutane sulfonate, Potassium salt (PFBS): A 48-hour static acute toxicity test with the cladoceran (Daphnia magna). Wildlife International Ltd., Project No. 454A-118A.

    Google Scholar 

  • Wildlife International Ltd (2001c) Perfluorobutane sulfonate, potassium salt (PFBS): A 96-hour static acute toxicity test with the fathead minnow (Pimephales promelas). Wildlife International Ltd., Project No. 454A-115.

    Google Scholar 

  • Wildlife International Ltd. (2001d) Perfluorobutane sulfonate, Potassium salt (PFBS): A 96-hour static acute toxicity test with bluegill (Lepomis macrochirus). Wildlife International Ltd., Project No. 454A-114.

    Google Scholar 

  • Wildlife International Ltd (2001e) PFBS: A 96-hour static acute toxicity test with the freshwater alga (Selenastrum capricornutum). Wildlife International Ltd., Project No. 454A-129.

    Google Scholar 

  • Wildlife International Ltd (2001f) PFBS: A 96-hour toxicity test with the saltwater mysid (Mysiodopsis bahia). Wildlife International Ltd., Project No. 454A-128.

    Google Scholar 

  • Wildlife International Ltd (2001g) PFBS: A semi-static life-cycle toxicity test with the cladoceran (Daphnia magna). Wildlife International Ltd., Project No. 454A-130.

    Google Scholar 

  • Yamada T, Taylor PH (2003) Laboratory-scale thermal degradation of perfluoro-octanyl sulfonate and related substances. Environmental Sciences and Engineering Group, University of Dayton, Research Institute, Dayton, OH.

    Google Scholar 

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Giesy, J.P., Naile, J.E., Khim, J.S., Jones, P.D., Newsted, J.L. (2010). Aquatic Toxicology of Perfluorinated Chemicals. In: Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 202. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1157-5_1

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