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Role of APC and Its Binding Partners in Regulating Microtubules in Mitosis

  • Chapter
APC Proteins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 656))

Abstract

Adenomatous polyposis coli (APC) is a multifunctional protein commonly mutated in colon cancer. APC contains binding sites for multiple proteins with diverse roles in signaling and the structural and functional organization of cells. Recent evidence suggests roles for APC and some of its binding partners in regulating microtubules in mitosis. APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis.

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Authors and Affiliations

  1. Department of Biological Sciences, Bio-X Program, The James H. Clark Center, Stanford University, 318 Campus Drive (E200), Stanford, California, 94305-5430, USA, USA

    Shirin Bahmanyar, W. James Nelson & Angela I. M. Barth

  2. Department of Biological Sciences and Molecular Cellular Physiology, Stanford University, Stanford, California, USA

    Shirin Bahmanyar & W. James Nelson

Authors
  1. Shirin Bahmanyar
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  2. W. James Nelson
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  3. Angela I. M. Barth
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Correspondence to Angela I. M. Barth .

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Editors and Affiliations

  1. Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Inke S. Näthke

  2. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

    Brooke M. McCartney

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Bahmanyar, S., Nelson, W.J., Barth, A.I.M. (2009). Role of APC and Its Binding Partners in Regulating Microtubules in Mitosis. In: Näthke, I.S., McCartney, B.M. (eds) APC Proteins. Advances in Experimental Medicine and Biology, vol 656. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1145-2_6

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