Abstract
The most important clinical manifestation of Familial Adenomatous Polyposis (FAP) is a profuse polyposis predisposing to colorectal cancer. This clinical picture emphasises the fundamental cellular role of APC in colorectal tumorigenesis. As prophylactic colorectal surgery has significantly reduced the mortality associated with this disorder, other less penetrant signs and symptoms of the condition are becoming more clinically relevant. Highlighting these problems will help improve the quality oflife for patients with FAP and may have the additional benefit of shedding new light on other possible functions of the APC protein.
Keywords
- Retinal Pigment Epithelium
- Papillary Thyroid Carcinoma
- Familial Adenomatous Polyposis
- Adenomatous Polyposis Coli
- Desmoid Tumor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Trainer, A.H. (2009). Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli. In: Näthke, I.S., McCartney, B.M. (eds) APC Proteins. Advances in Experimental Medicine and Biology, vol 656. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1145-2_10
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DOI: https://doi.org/10.1007/978-1-4419-1145-2_10
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