Abstract
Recently published data demonstrate that approximately 8 million men and women over 40 years of age have peripheral arterial disease and approximately, 20% of Americans greater than 65 years of age endure the symptoms of this disease process [1]. Despite its prevalence and cardiovascular risk implications, durable treatment options are limited, with only about 25% of PAD patients currently undergoing treatment. [2] Surgical revascularization using autologous vein remains among the dominant therapeutic options, with 110,000 peripheral bypass procedures performed in 2004. [1] Fueled by an epidemic of obesity and diabetes in the United States, substantial increases in the need for these interventions are projected over the next decade. Despite the escalating need for these often limb- and life-saving procedures, their medium and long-term durability remains compromised. Plagued by the problems of aggressive stenosis and luminal narrowing, contemporary data shows that almost 40% of lower extremity vein bypass grafts develop occlusive lesions or fail within a year (Fig. 1) [3]. Since many of the technical advancements for improved patency have been exhausted, the current concept is that the future of enhancing the durability of these reconstructions lies in a better understanding of the biology of the vein graft wall in response to interventions [4].
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Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O’Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinberger J, Thom T, Wasserthiel-Smoller S, Hong Y (2007) Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115:e69–171
Bhatt DL, Steg PG, Ohman EM, Hirsch AT, Ikeda Y, Mas JL, Goto S, Liau CS, Richard AJ, Rother J, Wilson PW (2006) International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 295:180–189
Conte MS, Bandyk DF, Clowes AW, Moneta GL, Seely L, Lorenz TJ, Namini H, Hamdan AD, Roddy SP, Belkin M, Berceli SA, DeMasi RJ, Samson RH, Berman SS (2006) Results of PREVENT III: a multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery. J Vasc Surg 43:742–751
Conte MS, Mann MJ, Simosa HF, Rhynhart KK, Mulligan RC (2002) Genetic interventions for vein bypass graft disease: a review. J Vasc Surg 36:1040–1052
Glagov S (1994) Intimal hyperplasia, vascular modeling, and the restenosis problem. Circulation 89:2888–2891
Glagov S, Bassiouny HS, Giddens DP, Zarins CK (1995) Pathobiology of plaque modeling and complication. Surg Clin North Am 75:545–556
Wentzel JJ, Krams R, Schuurbiers JC, Oomen JA, Kloet J, Der Giessen WJ, Serruys PW, Slager CJ (2001) Relationship between neointimal thickness and shear stress after Wallstent implantation in human coronary arteries. Circulation 103:1740–1745
Newby AC, Baker AH (1999) Targets for gene therapy of vein grafts. Curr Opin Cardiol 14:489–494
Bassiouny HS, White S, Glagov S, Choi E, Giddens DP, Zarins CK (1992) Anastomotic intimal hyperplasia: mechanical injury or flow induced. J Vasc Surg 15:708–716
Cambria RP, Megerman J, Brewster DC, Warnock DF, Hasson J, Abbott WM (1987) The evolution of morphologic and biomechanical changes in reversed and in-situ vein grafts. Ann Surg 205:167–174
Zhang WD, Bai HZ, Sawa Y, Yamakawa T, Kadoba K, Taniguchi K, Masuda J, Ogata J, Shirakura R, Matsuda H (1999) Association of smooth muscle cell phenotypic modulation with extracellular matrix alterations during neointima formation in rabbit vein grafts. J Vasc Surg 30:169–183
Zwolak RM, Adams MC, Clowes AW (1987) Kinetics of vein graft hyperplasia: association with tangential stress. J Vasc Surg 5:126–136
Mills JL, Sr., Wixon CL, James DC, Devine J, Westerband A, Hughes JD (2001) The natural history of intermediate and critical vein graft stenosis: recommendations for continued surveillance or repair. J Vasc Surg 33:273–278
Vesti BR, Primozich J, Bergelin RO, Strandness E Jr (2001) Follow-up of valves in saphenous vein bypass grafts with duplex ultrasonography. J Vasc Surg 33:369–374
DeBakey ME (1979) Research related to surgical treatment of aortic and peripheral vascular disease. Circulation 60:1619–1635
Fernandez CM, Goldman DR, Jiang Z, Ozaki CK, Tran-Son-Tay R, Berceli SA (2004) Impact of shear stress on early vein graft remodeling: a biomechanical analysis. Ann Biomed Eng 32:1484–1493
Jiang Z, Wu L, Miller BL, Goldman DR, Fernandez CM, Abouhamze ZS, Ozaki CK, Berceli SA (2004c) A novel vein graft model: adaptation to differential flow environments. Am J Physiol Heart Circ Physiol 286:H240-H245
Berceli SA, Jiang Z, Klingman NV, Schultz GS, Ozaki CK (2006) Early differential MMP-2 and -9 dynamics during flow-induced arterial and vein graft adaptations. J Surg Res 134: 327–334
Jiang Z, Berceli SA, Pfahnl CL, Wu L, Killingsworth CD, Vieira FG, Ozaki CK (2004b) Impact of IL-1beta on flow-induced outward arterial remodeling. Surgery 136:478–482
Jiang Z, Berceli SA, Pfahnl CL, Wu L, Goldman D, Tao M, Kagayama M, Matsukawa A, Ozaki CK (2004a) Wall shear modulation of cytokines in early vein grafts. J Vasc Surg 40:345–350
Jiang Z, Yu P, Tao M, Fernandez C, Ifantides C, Moloye O, Schultz GS, Ozaki CK, Berceli SA (2007b) TGF-beta- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling. Am J Physiol Heart Circ Physiol 293:H482-H488
Jiang Z, Shukla A, Miller BL, Espino DR, Tao M, Berceli SA, Ozaki CK (2007a) Tumor necrosis factor-alpha and the early vein graft. J Vasc Surg 45:169–176
Meyerson SL, Skelly CL, Curi MA, Shakur UM, Vosicky JE, Glagov S, Schwartz LB, Christen T, Gabbiani G (2001) The effects of extremely low shear stress on cellular proliferation and neointimal thickening in the failing bypass graft. J Vasc Surg 34:90–97
Schwartz LB, O’Donohoe MK, Purut CM, Mikat EM, Hagen PO, McCann RL (1992) Myointimal thickening in experimental vein grafts is dependent on wall tension. J Vasc Surg 15:176–186
Ribba B, Marron K, Agur Z, Alarcon T, Maini PK (2005) A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin’s lymphoma: investigation of the current protocol through theoretical modelling results. Bull Math Biol 67:79–99
Ribba B, Colin T, Schnell S (2006) A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies. Theor Biol Med Model 3:7
Li NY, Verdolini K, Clermont G, Mi Q, Rubinstein EN, Hebda PA, Vodovotz Y (2008) A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE 3:e2789
Mi Q, Riviere B, Clermont G, Steed DL, Vodovotz Y (2007) Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen 15:671–682
Loth F, Jones SA, Zarins CK, Giddens DP, Nassar RF, Glagov S, Bassiouny HS (2002) Relative contribution of wall shear stress and injury in experimental intimal thickening at PTFE end-to-side arterial anastomoses. J Biomech Eng 124:44–51
Yang C, Tang D, Liu SQ (2003) A multi-physics growth model with fluid-structure interactions for blood flow and re-stenosis in rat vein grafts: a growth model for blood flow and re-stenosis in grafts. Comput Struct 81:1041–1058
Serini G, Ambrosi D, Giraudo E, Gamba A, Preziosi L, Bussolino F (2003) Modeling the early stages of vascular network assembly. EMBO J 22:1771–1779
Bailey AM, Thorne BC, Peirce SM (2007) Multi-cell agent-based simulation of the microvasculature to study the dynamics of circulating inflammatory cell trafficking. Ann Biomed Eng 35:916–936
Thorne BC, Bailey AM, Peirce SM (2007) Combining experiments with multi-cell agent-based modeling to study biological tissue patterning. Brief Bioinform 8:245–257
Facciotti MT, Bonneau R, Hood L, Baliga NS (2004) Systems biology experimental design – Considerations for building predictive gene regulatory network models for prokaryotic systems. Curr Genomics 5:527–544
Kitano H (2002) Systems biology: a brief overview. Science 295:1662–1664
Ehsan A, Mann MJ, Dell’Acqua G, Dzau VJ (2001) Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. J Thorac Cardiovasc Surg 121:714–722
Ehsan A, Mann MJ, Dell’Acqua G, Tamura K, Braun-Dullaeus R, Dzau VJ (2002) Endothelial healing in vein grafts: proliferative burst unimpaired by genetic therapy of neointimal disease. Circulation 105:1686–1692
Mann MJ, Dzau VJ (2000) Therapeutic applications of transcription factor decoy oligonucleotides. J Clin Invest 106:1071–1075
Mann MJ, Whittemore AD, Donaldson MC, Belkin M, Conte MS, Polak JF, Orav EJ, Ehsan A, Dell’Acqua G, Dzau VJ (1999) Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial. Lancet 354:1493–1498
Mann MJ, Conte MS (2003) Transcription factor decoys for the prevention of vein bypass graft failure. Am J Cardiovasc Drugs 3:79–85
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Berceli, S.A., Tran-Son-Tay, R., Garbey, M. (2010). Emerging Mechanisms of Vein Graft Failure: The Dynamic Interaction of Hemodynamics and the Vascular Response to Injury. In: Garbey, M., Bass, B., Collet, C., Mathelin, M., Tran-Son-Tay, R. (eds) Computational Surgery and Dual Training. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1123-0_12
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