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Scale Up and Technology Transfer of Pharmaceutical Suspensions

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Pharmaceutical Suspensions

Abstract

Scaling up of suspension dosage form is considered a challenge as pharmaceutical suspensions are thermodynamically unstable. During the scale-up process, the effect of operational variables on the dispersion process, and physical properties affecting overall attributes need systematic evaluation. Though the scale up process can be studied using dimensional analysis, mathematical modeling, and computer simulation, most of the work in the field of suspension manufacturing still depends on empirical studies and the principles of geometric similarities. Various aspects of the scale up process, technology transfer, and process analytical technology (PAT) applications in suspension manufacturing are discussed.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Sullivan University, Louisville, KY, 40205, USA

    Yashwant Pathak

  2. President Pharmaceutical Development, Pharmanova Inc, Victor, NY, 14564, USA

    Deepak Thassu

Authors
  1. Yashwant Pathak
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  2. Deepak Thassu
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Correspondence to Yashwant Pathak .

Editor information

Editors and Affiliations

  1. Alcon Research Ltd., S. Freeway 6201, Forth Worth, 76134, U.S.A.

    Alok K. Kulshreshtha

  2. Alcon Research Ltd., S. Freeway 6201, Forth Worth, 76134, U.S.A.

    Onkar N. Singh

  3. Alcon Research Ltd., S. Freeway 6201, Forth Worth, 76134, U.S.A.

    G. Michael Wall

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Pathak, Y., Thassu, D. (2010). Scale Up and Technology Transfer of Pharmaceutical Suspensions. In: Kulshreshtha, A., Singh, O., Wall, G. (eds) Pharmaceutical Suspensions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1087-5_8

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