Abstract
The suspension must be physically stable (no appreciable settling) for a sufficient time, chemically stable over the required time (shelf-life), possess a viscosity that allows it to be used for its intended purpose, be easily reconstituted (redispersible) upon shaking, easy to manufacture and be acceptable in use to the patient, care-giver or other user. This chapter deals in-depth, with the role and selection of commonly used excipients in developing stable pharmaceutical suspension dosage forms.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Belitz, H.-D., Grosch, W., and Schieberle, P. 2004. Food Chemistry, 3rd Edition, Springer-Verlag, Berlin, Heidelberg.
Galichet, L.Y. 2006. Iron Oxides, In Handbook of Pharmaceutical Excipients, 5th Edition, Rowe, R.C., Sheskey, P.J., and Owen, S.C. (eds.), Pharmaceutical Press, London, and American Pharmaceutical Association, Washington, DC, 364–365.
Guidance for Industry: Nonclinical Studies for the Safety Evaluation of Pharmaceutical Excipients, Food and Drug Administration, Rockville, MD, May 2005.
ICH Q8: Pharmaceutical Development, Step 4 Document, International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, Geneva, Switzerland, November 2005.
Inactive Ingredient Database, US Food and Drug Administration – Center for Drug Evaluation and Research, http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm.
Moreton, R.C. 1996. Tablet excipients to the year 2001: a look into the crystal ball, Drug Dev. Ind. Pharm. 22(1), 11–23.
Mroz, C. 2006. Coloring Agents, In Handbook of Pharmaceutical Excipients, 5th Edition, Rowe, R.C., Sheskey, P.J., and Owen, S.C. (eds.), Pharmaceutical Press, London, and American Pharmaceutical Association, Washington, DC, 192–200.
Niazi, S.K. 2004a. Handbook of Pharmaceutical Manufacturing Formulations: Volume 3 Liquid Products, CRC Press, Boca Raton, FL.
Niazi, S.K. 2004b. Handbook of Pharmaceutical Manufacturing Formulations: Volume 5 Over-the-Counter Products, CRC Press, Boca Raton, FL.
Rowe, R.C., Sheskey, P.J., and Owen, S.C. 2006. Handbook of Pharmaceutical Excipients, 5th Edition, Pharmaceutical Press, London, and American Pharmaceutical Association, Washington, DC.
Steele, D.F., Edge, S., Tobyn, M.J., Moreton, R.C., and Staniforth, J.N. 2003. Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples. Drug Dev. Ind. Pharm. 29(4), 475–487.
United States Pharmacopeia 30 – National Formulary 25, United States Pharmacopeia Convention, Inc., Rockville, MD, 2007.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 AAPS
About this chapter
Cite this chapter
Moreton, R.C. (2010). Commonly Used Excipients in Pharmaceutical Suspensions. In: Kulshreshtha, A., Singh, O., Wall, G. (eds) Pharmaceutical Suspensions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1087-5_3
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1087-5_3
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1086-8
Online ISBN: 978-1-4419-1087-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)
