Skip to main content
SpringerLink
Log in
Book cover

Atlas of Pediatric Brain Tumors pp 63–73Cite as

Central Nervous System Primitive Neuroectodermal Tumors and Medulloepithelioma

  • Chapter
  • First Online:

  • 2206 Accesses

Abstract

Embryonal tumors at extracerebellar sites are composed of undifferentiated neuroepithelial cells with capacity for divergent differentiation, including neuronal, astrocytic, myoid, or melanocytic differentiation. Tumors may recapitulate the primitive neural tube (medulloepithelioma) or have ependymoblastomatous rosettes (ependymoblastoma) or have extensive neuronal differentiation (cerebral neuroblastoma) with ganglion cells (ganglioneuroblastoma).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Suggested Reading

  • Bennet JP Jr, Rubinstein LJ (1984) The biological behavior of primary cerebral neuroblastoma: a reappraisal of the clinical course in a series of 70 cases. Ann Neurol 16:21–27

    Article  Google Scholar 

  • Rubinstein LJ (1970) The definition of the ependymoblastoma. Arch Pathol 90:35–45

    PubMed  CAS  Google Scholar 

  • Cruz-Sanchez FF, Haustein J, Rossi M et al (1988) Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. Histopathology 12:17–27

    Article  PubMed  CAS  Google Scholar 

  • Rorke LB (1983) The cerebral medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42:1–15

    Article  PubMed  CAS  Google Scholar 

  • Gould VE, Rorke LB, Jansson DS, Molenaar WM, Trojanowski JQ, Lee VM, Packer RJ, Franke WW (1990) Primitive neuroectodermal tumors of the central nervous system express neuroendocrine markers and may express all classes of intermediate filaments. Hum Pathol 21:245–252

    Article  PubMed  CAS  Google Scholar 

  • Burnett ME, White EC, Sih S, von Haken MS, Cogen PH (1997) Chromosome 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system. Cancer Genet Cytogenet 97:25–31

    Article  PubMed  CAS  Google Scholar 

  • Karch SB, Urich H (1972) Medulloepithelioma: definition of an entity. J Neuropath Exp Neurol 31:27–53

    Article  PubMed  CAS  Google Scholar 

  • Jellinger K (1972) Cerebral medulloepithelioma. Acta Neuropathol 22:95–101

    Article  PubMed  CAS  Google Scholar 

  • Becker LE, Sharma MC, Rorke LB (2000) Medulloepithelioma. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. IARC, Lyon, pp 124–126

    Google Scholar 

  • Coccamo DV, Herman MM, Rubinstein LJ (1989) An immunohistochemical study of the primitive and maturing elements of human cerebral medulloepitheliomas. Acta Neuropathol 79:248–254

    Article  Google Scholar 

  • Auer RN, Becker LE (1983) Cerebral medulloepithelioma with bone, cartilage, and striated muscle. Light microscopic and immunohistochemical study. J Neuropathol Exp Neurol 42:256–267

    Article  PubMed  CAS  Google Scholar 

  • Louis DN, Reifenberger G, Brat DJ, Ellison DW (2008) Tumours: introduction and neuroepithelial tumours. In: Love S, Louis DN, Ellison DW (eds) Greenfield’s Neuropathology, 8th edn. Hodder Arnold, London, pp 1960–1961

    Google Scholar 

  • Figeroa RE, el Gammal T, Brooks BS et al (1989) MR findings on primitive neuroectodermal tumors. J Comput Assist Tomogr 13:773–778

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Neuropathology and Molecular Neuropathology Laboratory, Department of Pathology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

    Adekunle M. Adesina M.D., Ph.D. (Professor of Pathology, Medical Director)

  2. Department of Radiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

    J. Hunter (Associate Professor of Radiology)

  3. Department of Pathology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    L. Rorke-Adams (Clinical Professor)

Authors
  1. Adekunle M. Adesina M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Rorke-Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. Pathology, Baylor College of Medicine, Baylor Plaza 1, Houston, 77030, U.S.A.

    Adekunle M. Adesina

  2. School of Medicine, University of California, Parnassus Ave. 505, San Francisco, 94143, U.S.A.

    Tarik Tihan

  3. VCU Medical Center, Virginia Commonwealth University, E. Marshall Street 1200, Richmond, 23298, U.S.A.

    Christine E. Fuller

  4. Children's Hospital Boston, Harvard Medical School, Longwood Ave. 300, Boston, 02115, U.S.A.

    Tina Young Poussaint

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Adesina, A.M., Hunter, J., Rorke-Adams, L. (2010). Central Nervous System Primitive Neuroectodermal Tumors and Medulloepithelioma. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-1062-2_6

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1061-5

  • Online ISBN: 978-1-4419-1062-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation