Abstract
A group of glial tumors exhibiting ependymal differentiation including subependymoma (WHO grade I), myxopapillary ependymoma (WHO grade I), ependymoma (WHO grade II; variants including cellular, tanycytic, papillary, and clear cell), and anaplastic ependymoma (WHO grade III). Most are sporadic; ependymomas may be seen as part of neurofibromatosis type 2, a hereditary cancer predisposition syndrome with germline mutation of NF2/Merlin gene. Recent evidence supports radial glia as the candidate cell of origin for ependymomas; subependymomas appear to derive from subependymal glial precursors.
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Fuller, C.E., Narendra, S., Tolicica, I. (2010). Ependymal Tumors. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_5
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DOI: https://doi.org/10.1007/978-1-4419-1062-2_5
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