Abstract
Malignant neoplasms arising in association with peripheral nerves and resembling elements of the peripheral nerve are considered in this category. These tumors may arise in the setting of neurofibromatosis or may be seen sporadically in children. The unequivocal recognition of a high grade sarcoma as malignant peripheral nerve sheath tumor (MPNST) requires that the tumor clearly arises from a peripheral nerve, emerge from a benign peripheral nerve sheath tumor such as neurofibroma or schwannoma, or demonstrate histological, immunohistochemical, and ultrastructural evidence of peripheral nerve tissue differentiation.
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Tihan, T. (2010). Malignant Peripheral Nerve Sheath Tumors. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_15
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DOI: https://doi.org/10.1007/978-1-4419-1062-2_15
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