Abstract
Hemangioblastomas are highly vascular tumors that are typically benign and slow-growing, corresponding to WHO grade I. They may occur sporadically or in the context of Von Hippel-Lindau (VHL) syndrome (see Sect. F); the former predominates. They have also been referred to as capillary hemangioblastomas. Though it is clearly the stromal cell that is the neoplastic component in these tumors, the underlying cell of origin has yet to be determined.
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Conway JE, Chou D, Clatterbuck RE, Brem H, Long DM, Rigamonti D (2001) Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease. Neurosurgery 48(1):55–62
Lach B, Gregor A, Rippstein P, Omulecka A (1999) Angiogenic histogenesis of stromal cells in hemangioblastoma: Ultrastructural and immunohistochemical study. Ultrastruct Pathol 23(5):299–310
Chaudhry AP, Montes M, Cohn GA (1978) Ultrastructure of cerebellar hemangioblastoma. Cancer 42(4):1834–1850
Roy S, Chu A, Trojanowski JQ, Zhang PJ (2005) D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol (Berl) 109(5):497–502
Weinbreck N, Marie B, Bressenot A, Montagne K, Joud A, Baumann C et al (2008) Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: Utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. Am J Surg Pathol 32(7):1051–1059
Lallu S, Naran S, Palmer D, Bethwaite P (2008) Cyst fluid cytology of cerebellar hemangioblastoma: A case report. Diagn Cytopathol 36(5):341–343
Jagannathan J, Lonser RR, Smith R, DeVroom HL, Oldfield EH (2008) Surgical management of cerebellar hemangioblastomas in patients with von Hippel-Lindau disease. J Neurosurg 108(2):210–222
Rodesch G, Gaillard S, Loiseau H, Brotchi J (2008) Embolization of intradural vascular spinal cord tumors: Report of five cases and review of the literature. Neuroradiology 50(2):145–151
Koh ES, Nichol A, Millar BA, Menard C, Pond G, Laperriere NJ (2007) Role of fractionated external beam radiotherapy in hemangioblastoma of the central nervous system. Int J Radiat Oncol Biol Phys 69(5):1521–1526
Lemeta S, Jarmalaite S, Pylkkanen L, Bohling T, Husgafvel-Pursiainen K (2007) Preferential loss of the nonimprinted allele of ZAC1 tumor suppressor gene in human capillary hemangioblastoma. J Neuropathol Exp Neurol 66(9):860–867
Glasker S (2005) Central nervous system manifestations in VHL: Genetics, pathology and clinical phenotypic features. Fam Cancer 4(1):37–42
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Fuller, C.E. (2010). Hemangioblastoma. In: Adesina, A., Tihan, T., Fuller, C., Poussaint, T. (eds) Atlas of Pediatric Brain Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1062-2_12
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DOI: https://doi.org/10.1007/978-1-4419-1062-2_12
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