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Osteoimmunology pp 69–75Cite as

NFATc1 in Inflammatory and Musculoskeletal Conditions

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 658))

Abstract

The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contributed to our understanding of this transcription factor in inflammatory and musculoskeletal conditions and their treatment.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology, Allergy and Immunology and Department of Infectious Disease and Immunology, Harvard Medical School, Brigham and Women’s Hospital, Harvard School of Public Health, Boston, MA, USA

    Antonios O. Aliprantis

  2. Department of Infectious Disease and Immunology and Department of Medicine, Division of Rheumatology, Allergy and Immunology, Harvard School of Public Health, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Laurie H. Glimcher

Authors
  1. Antonios O. Aliprantis
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  2. Laurie H. Glimcher
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Corresponding author

Correspondence to Antonios O. Aliprantis .

Editor information

Editors and Affiliations

  1. School of Medicine, University of Pennsylvania, Curie Blvd., Philadelphia, 19104, U.S.A.

    Yongwon Choi

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Aliprantis, A.O., Glimcher, L.H. (2009). NFATc1 in Inflammatory and Musculoskeletal Conditions. In: Choi, Y. (eds) Osteoimmunology. Advances in Experimental Medicine and Biology, vol 658. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1050-9_8

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