The Unexpected Link Between Osteoclasts and the Immune System
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Osteoimmunology is an interdisciplinary research field focused on the molecular understanding of the interplay of the skeletal and immune systems. In particular, the interaction between immune cells and osteoclasts is a current major topic of critical interest in this field. The macrophage-osteoclast interaction has long been studied, and the T-cellosteoclast interaction also attracted much attention in the study of arthritis. However, recent reports have revealed a hitherto unknown link between osteoclasts and other immune cells, including B cells and dendritic cells, suggesting a larger number of molecules are in fact shared by osteoclasts and immune cells. These findings will lead to a better understanding of the pathogenesis of diseases affecting both systems and may/will provide a molecular basis for novel therapeutic strategies.
KeywordsOsteoclast T cells RANKL NFATc1 Cathepsin K
This work was supported in part by Grant-in-Aid for Creative Scientific Research from the Japan Society for the Promotion of Science (JSPS); grants for the Genome Network Project and the Global Center of Excellence (GCOE) Program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT); and grants from Tokyo Biochemical Research Foundation, Yokoyama Foundation for Clinical Pharmacology, the Japan Medical Association and Takeda Science Foundation.