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The Unexpected Link Between Osteoclasts and the Immune System

  • Hiroshi TakayanagiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 658)

Abstract

Osteoimmunology is an interdisciplinary research field focused on the molecular understanding of the interplay of the skeletal and immune systems. In particular, the interaction between immune cells and osteoclasts is a current major topic of critical interest in this field. The macrophage-osteoclast interaction has long been studied, and the T-cellosteoclast interaction also attracted much attention in the study of arthritis. However, recent reports have revealed a hitherto unknown link between osteoclasts and other immune cells, including B cells and dendritic cells, suggesting a larger number of molecules are in fact shared by osteoclasts and immune cells. These findings will lead to a better understanding of the pathogenesis of diseases affecting both systems and may/will provide a molecular basis for novel therapeutic strategies.

Keywords

Osteoclast T cells RANKL NFATc1 Cathepsin K 

Notes

Acknowledgments

This work was supported in part by Grant-in-Aid for Creative Scientific Research from the Japan Society for the Promotion of Science (JSPS); grants for the Genome Network Project and the Global Center of Excellence (GCOE) Program from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT); and grants from Tokyo Biochemical Research Foundation, Yokoyama Foundation for Clinical Pharmacology, the Japan Medical Association and Takeda Science Foundation.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Cell SignalingGraduate School, Tokyo Medical and Dental UniversityTokyoJapan

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