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Regulation of Osteoclast Apoptosis by Bcl-2 Family Protein Bim and Caspase-3

  • Sakae Tanaka
  • Hidetoshi Wakeyama
  • Toru Akiyama
  • Katsuhiko Takahashi
  • Hitoshi Amano
  • Keiichi I. Nakayama
  • Kozo Nakamura
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 658)

Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 –/– mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Keywords

Osteoclast Apoptosis Bim Caspase-3 

Notes

Acknowledgments

This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Health Science research grants from the Ministry of Health, Labor, and Welfare of Japan to S.T.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sakae Tanaka
    • 1
  • Hidetoshi Wakeyama
    • 1
  • Toru Akiyama
    • 1
  • Katsuhiko Takahashi
    • 2
  • Hitoshi Amano
    • 3
  • Keiichi I. Nakayama
    • 4
  • Kozo Nakamura
    • 5
  1. 1.Department of Orthopaedic SurgeryFaculty of Medicine, The University of TokyoTokyoJapan
  2. 2.Department of Biological ChemistrySchool of Pharmaceutical Sciences, Showa UniversityTokyoJapan
  3. 3.Department of PharmacologySchool of Dentistry, Showa UniversityTokyoJapan
  4. 4.Department of Molecular and Cellular BiologyMedical Institute of Bioregulation, Kyushu UniversityFukuokaJapan
  5. 5.Department of Orthopaedic SurgeryFaculty of MedicineTokyoJapan

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