Myoglobin and Hemoglobin

  • Hans Frauenfelder
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


Hemoglobin is the vital protein that conveys oxygen from the lungs to the tissues and facilitates the return of carbon dioxide from the tissues back to the lungs [1]–[6]. Myoglobin accepts and stores the oxygen released by hemoglobin and transports it to the mitochondria. The pathways are shown in Fig. 10.1. Together, these two proteins show how protein structure determines function and how Nature uses components, in this case myoglobin, to build more complex proteins consisting of functional subunits. In Part III we explore myoglobin dynamics in more depth; this chapter provides a brief overview of a very complex system and points to why Part III will concentrate on myoglobin rather than hemoglobin.


Partial Oxygen Pressure Hill Plot Species Adaptation Binding Curve Functional Subunit 
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  1. 1.
    M. Weissbluth. Hemoglobin. Springer, New York, 1974.CrossRefGoogle Scholar
  2. 2.
    M. F. Perutz. Hemoglobin structure and respiratory transport. Sci. American, 239(6):92–125, 1978.CrossRefGoogle Scholar
  3. 3.
    J. M. Berg, J. L. Tymoczko, and L. Stryer. Biochemistry, 6th edition. W. H. Freeman, New York, 2006.Google Scholar
  4. 4.
    M. F. Perutz. Species adaptation in a protein molecule. Mol. Bio. Evol., 1:1–28, 1983.Google Scholar
  5. 5.
    M. F. Perutz. Mechanisms of cooperativity and allosteric regulation in proteins. Q. Rev. Biophys, 22:139–236, 1989.CrossRefGoogle Scholar
  6. 6.
    R. E. Dickerson and I. Geis. Hemoglobin. Benjamin/Cumming, Menlo Park, CA, 1983.Google Scholar
  7. 7.
    A. C. T. North and J. E. Lydon. The evolution of biological macromolecules. Contemp. Phys, 25:381–93, 1984.CrossRefADSGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Hans Frauenfelder
    • 1
  1. 1.Theory DivisionLos Alamos National LaboratoryLos AlamosUSA

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