Abstract
Entorhinal cortex (EC) has recently gained increased interest following the findings of grid cells (Fyhn et al., 2004; Hafting et al., 2005). It has also recently been shown that place cells, intensely studied in the hippocampus, exist upstream of hippocampus in superficial layers of entorhinal cortex (Fyhn et al., 2004). In the light of these findings, mechanisms generating the gradient in rhythmicity of entorhinal grid cells have received large interest (Giocomo et al., 2007). In previous work we have studied the ionic mechanisms behind the subthreshold membrane potential oscillations found in layer II stellate cells experimentally (Klink and Alonso, 1993, Dickson et al., 2000) and using modeling (Dickson et al., 2000; Fransén et al., 2004). Moreover, the entorhinal cortex has also been shown to be specifically involved in the representation of novel items in working memory experiments in humans (Stern et al., 2001; Schön et al., 2004, 2005) and rodents (McGaughy et al., 2005).
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Alonso, A., & Klink, R. (1993). Differential electroresponsiveness of stellate and pyramidal-like cells of medial entorhinal cortex layer II. J Neurophysiol, 70, 128–143.
Bunce, J. G., Sabolek, H. R., & Chrobak, J. J. (2004). Intraseptal infusion of the cholinergic agonist carbachol impairs delayed-non-match-to-sample radial arm maze performance in the rat. Hippocampus, 14, 450–459.
Dickson, C., Magistretti, J., Shalinsky, M. H., Fransén, E., Hasselmo, M., & Alonso, A. (2000). Properties and role of Ih in the pacing of subthreshold oscillations in entorhinal cortex layer II neurons. J Neurophysiol, 83, 2562–2579.
Egorov, A. V., Hamam, B. N., Fransén, E., Hasselmo, M. E., & Alonso, A. A. (2002). Graded persistent activity in entorhinal cortex neurons. Nature, 420, 173–178.
Ekeberg, Ö., Wallén, P., Lansner, A., Tråvén, H., Brodin, L., & Grillner, S. (1991). A computer based model for realistic simulations of neural networks. I. The single neuron and synaptic interaction. Biol Cybern, 65, 81–90.
Fransén, E., Alonso, A. A., Dickson, C. T., Magistretti, J., & Hasselmo, M. E. (2004). Ionic mechanisms in the generation of subthreshold oscillations and action potential clustering in entorhinal layer II stellate neurons. Hippocampus, 14, 368–384.
Fransén, E., Alonso, A. A., & Hasselmo, M. E. (2002). Simulations of the role of the muscarinic-activated calcium-sensitive non-specific cation current INCM in entorhinal neuronal activity during delayed matching tasks. J Neurosci, 22, 1081–1097.
Fransén, E., Tahvildari, B., Egorov, A. V., Hasselmo, M. E., & Alonso, A. A. (2006). Mechanism of graded persistent cellular activity of entorhinal cortex layer V neurons. Neuron, 49, 735–746.
Fyhn, M., Molden, S., Witter, M., Moser, E., & Moser, M.-B. (2004). Spatial representation in the entorhinal cortex. Science, 305, 1258–1264.
Giocomo, L. M., Zilli, E. A., Fransén, E., & Hasselmo, M. E. (2007, Mar 23). Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing. Science, 315(5819), 1719–1722.
Gloveli, T., Egorov, A. V., Schmitz, D., Heinemann, U., & Mller, W. (1999, Oct). Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III. Eur J Neurosci, 11(10), 3626–3636.
Hafting, T., Fyhn, M., Molden, S., Moser, M. B., & Moser, E. I. (2005, Aug 11). Microstructure of a spatial map in the entorhinal cortex. Nature, 436(7052), 801–806.
Hamam, B. N., Kennedy, T. E., Alonso, A., & Amaral, D. G. (2000, Mar 20) Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex. J Comp Neurol, 418(4), 457–472.
Kay, L. M. (2005). Theta oscillations and sensorimotor performance. Proc Natl Acad Sci USA, 102, 3863–3868.
Klink, R., & Alonso, A. (1993, Jul). Ionic mechanisms for the subthreshold oscillations and differential electroresponsiveness of medial entorhinal cortex layer II neurons. J Neurophysiol, 70(1), 144–57.
Klink, R., & Alonso, A. (1997). Morphological characteristics of layer II projection neurons in the rat medial entorhinal cortex. Hippocampus, 7(5), 571–583.
Lee, H., Simpson, G. V., Logothetis, N. K., & Rainer, G. (2005). Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex. Neuron, 45, 147–156.
Lisman, J. E., & Goldring, M. A. (1988, Jul). Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density. Proc Natl Acad Sci USA, 85(14), 5320–5324.
McCormick, D. A., & Huguenard, J. R. (1992, Oct). A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol, 68(4), 1384–1400.
McGaughy, J., Koene, R. A., Eichenbaum, H., & Hasselmo, M. E. (2005, Nov 2). Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task. J Neurosci, 25(44), 10273–10281.
Schön, K., Atri, A., Hasselmo, M. E., Tricarico, M. D., LoPresti, M. L., & Stern, C. E. (2005). Scopolamine reduces persistent activity related to long-term encoding in the parahippocampal gyrus during delayed matching in humans. J Neurosci, 25, 9112–9123.
Schön, K., Hasselmo, M. E., Lopresti, M. L., Tricarico, M. D., & Stern, C. E. (2004). Persistence of parahippocampal representation in the absence of stimulus input enhances long-term encoding: A functional magnetic resonance imaging study of subsequent memory after a delayed match-to-sample task. J Neurosci, 24, 11088–11097.
Stern, C. E., Sherman, S. J., Kirchhoff, B. A., & Hasselmo, M. E. (2001). Medial temporal and prefrontal contributions to working memory tasks with novel and familiar stimuli. Hippocampus, 11(4), 337–346.
Suzuki, W. A., Miller, E. K., & Desimone R. (1997, Aug). Object and place memory in the macaque entorhinal cortex. J Neurophysiol, 78(2), 1062–1081.
Tahvildari, B., Fransén, E., Alonso, A. A., & Hasselmo, M. E. (2007). Switching between “On” and “Off” states of persistent activity in lateral entorhinal layer III neurons. Hippocampus, 17(4), 257–263.
Traub, R. D., Wong, R. K., Miles, R., & Michelson, H. (1991 Aug). A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J Neurophysiol, 66(2), 635–650.
Yamada, W., Koch, C., & Adams, P. (1989). Multiple channels and calcium dynamics. In: C. Koch and I. Segev, Editors, Methods in Neuronal Modeling. From Synapses to Networks, MIT Press, Cambridge, MA, pp. 97–134.
Young, B. J., Otto, T., Fox, G. D., & Eichenbaum, H. (1997, Jul 1). Memory representation within the parahippocampal region. J Neurosci, 17(13), 5183–5195.
Zador, A., Koch, C., & Brown, T. H. (1990 Sep). Biophysical model of a Hebbian synapse. Proc Natl Acad Sci USA, 87(17), 6718–6722.
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Fransén, E. (2010). Entorhinal Cortex Cells. In: Cutsuridis, V., Graham, B., Cobb, S., Vida, I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0996-1_13
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DOI: https://doi.org/10.1007/978-1-4419-0996-1_13
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