Kinetics of Chemo/Biosensors



An insight into biosensor kinetics has been presented in this chapter with a focus on analyte–receptor interactions on biosensor surfaces. The vast applications of sensors are rapidly increasing, especially in the areas of medicine, food and drug administration and detection of toxic substances in various fields, and industrial applications. The Surface Plasmon Resonance (SPR) Biosensor is a dynamic equipment for measuring signals in analyte–receptor systems and is the main medium through which all the data in this chapter are obtained. A fractal analysis (single and dual) is presented here in an attempt to model the kinetic data obtained from literature to obtain important kinetic parameters such as the binding and dissociation rate constants, affinity, and fractal dimension values.

Examples are cited for the binding of liquid petroleum gas (LPG) to zinc oxide films prepared by the spray pyrolysis method onto a glass substrate (Sens and Actuator B 120: 551–559, 2007) and the binding of different NH3 concentrations in air to a sol-gel derived thin film (Sens and Actuator B 110:299–303, 2005). Since the major focus of this chapter is the kinetics, only scant information, if any, is presented on thermodynamics in these system interactions. However, fractal analysis provides a unique perspective of these molecular interactions and could be applied in other systems.


Biosensors Kinetics Binding Dissociation Fractals 



Surface plasmon resonance


Liquid petroleum gas




Barium strontium titanate




T4 polynucleotide kinase


Oligonucleotide sequence (5-3′)


Adenosine triphosphate


Deoxyribonucleic acid


Attenuated total reflection


Biomolecular interaction analysis


Surface plasmons










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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Chemical Engineering DepartmentUniversity of MississippiUniversityUSA

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