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Brain Anatomical Abnormalities in Schizophrenia: Neurodevelopmental Origins and Patterns of Progression over Time

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Advances in Schizophrenia Research 2009

Abstract

In his first delineation of the concept of dementia praecox at the end of the nineteenth century, Emil Kraepelin proposed the existence of progressive degenerative neuronal changes underlying the symptoms of this disorder, soon later renamed as schizophrenia by Eugen Bleuler (see review by DeLisi, 2008). On the basis of Kraepelin’s writings, a number of authors have, over several decades, formulated theories proposing that schizophrenia should be seen as a neurodegenerative disorder.

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Authors and Affiliations

  1. Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil

    Geraldo F. Busatto

  2. Laboratory of Psychiatric Neuroimaging (LIM21) Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, 05403–903, São Paulo, SP, Brazil

    Marcus V. Zanetti, Maristela S. Schaufelberger & José A.S. Crippa

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    Wagner F. Gattaz

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    Geraldo Busatto

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Busatto, G.F., Zanetti, M.V., Schaufelberger, M.S., Crippa, J.A. (2010). Brain Anatomical Abnormalities in Schizophrenia: Neurodevelopmental Origins and Patterns of Progression over Time. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_6

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