Abstract
Among numerous impediments to further advancement between the fifth and sixth symposia on Search for the Causes of Schizophrenia, several uncertainties endure: (i) What are the boundaries of psychotic illness? (ii) Where do we position what we currently conceptualise and diagnose as schizophrenia within the much broader reality of psychotic disorder among those with serious mental illness and, indeed, of psychotic phenomena among the general population? (iii) To what extent are those components of psychotic illness that we resolve into separate diagnostic categories actually distinct in any fundamental way in terms of their epidemiological, clinical and pathobiological ‘signature’?
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References
Baldwin PA, Scully PJ, Quinn JF, Morgan MG, Kinsella A, Owens JM, O’Callaghan E, Waddington JL (2005) Schizophrenia Bulletin 31:624–638, 2005
Browne S, Clarke M, Gervin M, Waddington JL, Larkin C, O’Callaghan E (2000) Determinants of quality of life at first presentation with schizophrenia. British Journal of Psychiatry 176: 173–176
Clarke M, Whitty P, Browne S, McTigue O, Kamali M, Gervin M, Kinsella A, Waddington JL, Larkin C, O’Callaghan, E (2006) Untreated illness and outcome of psychosis. British Journal of Psychiatry 189:235–240
Diewert VM, Lozanoff S, Choy, V (1993) Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation. Journal of Craniofacial Genetics and Developmental Biology 13:193–201
Dutta R, Greene T, Addington J, McKenzie K, Phillips M, Murray RM (2007) Biological, life course, and cross-cultural studies all point toward the value of dimensional and developmental ratings in the classification of psychosis. Schizophrenia Bulletin 33:868–876
Hennessy RJ, Kinsella A, Waddington JL (2002) 3D laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism. Biological Psychiatry 51:507–514
Hennessy RJ, Lane A, Kinsella A, Larkin C, O’Callaghan E, Waddington JL (2004) 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia. Schizophrenia Research 67:261–268
Hennessy RJ, McLearie S, Kinsella A, Waddington JL (2005) Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerbral-craniofacial morphogenesis and cognitive function. Journal of Anatomy 207:283–296
Hennessy RJ, Baldwin PA, Browne DJ, Kinsella A, Waddington JL (2007) Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia. Biological Psychiatry 61:1187–1194
Ivleva E, Thaker G, Tamminga CA (2008) Comparing genes and phenomenology in the major psychoses: schizophrenia and bipolar 1 disorder. Schizophrenia Bulletin 34:734–742
Jablensky A (1999) The conflict of the nosologists: views on schizophrenia and manic-depressive illness in the early part of the 20th century. Schizophrenia Research 39:95–100
Lane A, Kinsella A, Murphy P, Byrne M, Keenan J, Colgan K, Cassidy B, Sheppard N, Horgan R, Waddington JL, Larkin C, O’Callaghan E (1997) The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychological Medicine 27:1155–1164, 1997
Maier W, Zobel A, Wagner M (2006) Schizophrenia and bipolar disorder: differences and overlap. Current Opinion in Psychiatry 19:165–170
Marcucio RS, Cordero DR, Hu D, Helms JA (2005) Molecular interactions coordinating the development of the forebrain and face. Developmental Biology 284:48–61
McCauley M, Rooney S, Clarke C, Carey T, Owens J (2003) Home-based treatment in Monaghan: the first two years. Irish Journal of Psychological Medicine 20:11–14
McGrath JC, El-Saadi O, Grim V, Cardy S, Chapple B, Chant D, Lieberman D, Mowry B (2002) Minor physical anomalies and quantitative measures of the head and face in psychosis. Archives of General Psychiatry 59:458–464
McGrath JJ, Féron FP, Burne TH, Mackay-Sim A, Eyles DW (2003) The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Annals of Medicine 35(2):86–93
Rapoport JL, Addington AM, Frangou S (2005) The neurodevelopmental model of schizophrenia: update 2005. Molecular Psychiatry 10:434–449
Russell V, McCauley M, McMahon J, Casey S, McCullagh H, Begley J (2003) Liaison psychiatry in rural general practice. Irish Journal of Psychological Medicine 20:65–68
Schneider RA, Hu D, Rubenstein JLR, Maden M, Helms JA (2001) Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH- Development 128:2755–2767
Scully PJ, Quinn JF, Morgan MG, Kinsella A, O’Callaghan E, Owens JM, Waddington JL (2002) First episode schizophrenia, bipolar disorder and other psychoses in a rural Irish catchment area: incidence and gender in the Cavan–Monaghan study at 5 years. British Journal of Psychiatry 181 (Suppl. 43):s3–s9
Scully PJ, Owens JM, Kinsella A, Waddington JL (2004) Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate. Schizophrenia Research 67:143–155
Selten JP, Cantor-Graae E, Kahn RS (2007) Migration and schizophrenia. Current Opinion in Psychiatry 20:111–115
Waddington JL, Lane A, Larkin C, O’Callaghan E (1999) The neurodevelopmental basis of schizophrenia: clinical clues from cerebro-craniofacial dysmorphogenesis, and the roots of a lifetime trajectory of disease. Biological Psychiatry 46:31–39
Waddington JL, Corvin AP, Donohue G, O’Tuathaigh CMP, Mitchell KJ, Gill M (2007) Functional genomics and schizophrenia: endophenotypes and mutant models. Psychiatric Clinics of North America 30:365–399
Acknowledgments
The Cavan–Monaghan First-Episode Study was supported initially by the Stanley Medical Research Institute and, subsequently, by Cavan–Monaghan Mental Health Service. Studies on the developmental pathobiology of psychosis are supported by Science Foundation Ireland. We thank the clinical teams and associated staff of Cavan–Monaghan Mental Health Service for their important contributions and Dr. Ronan Conroy, Department of Epidemiology, for assistance with incidence analyses.
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Owoeye, O. et al. (2010). The ‘Totality’ of Psychosis: Epidemiology and Developmental Pathobiology. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_21
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