Gene–Environment Interactions for Searchers: Collaboration between Epidemiology and Molecular Genetics

Chapter

Abstract

Attempts to discover genes that relate directly to psychotic disorder (i.e., the simple “main effects” approach) have been frustrating and often disappointing, resulting in the expression of methodological concerns (Harrison and Weinberger 2005; Norton et al. 2006) (Collier 2008; Sullivan 2008; O’Donovan et al. 2008; Crow 2008). On the other hand, epidemiological research has unveiled high observed rates of schizophrenia in large cities, immigrant populations, traumatised individuals and cannabis users, at least some of which is thought to be the result of underlying environmental exposures. Exciting findings in other areas of psychiatry have motivated researchers to turn their attention to better understanding the complex ways in which nature interacts with nurture to produce psychosis.

Keywords

Migration Depression Dopamine Schizophrenia Aldehyde 

Notes

Acknowledgment

Parts of this chapter appeared as: van Os, J., Poulton, R. (2008). Environmental vulnerability and genetic-environmental interactions. In: The Recognition and Management of Early Psychosis: A Preventive Approach, 2nd edition (eds. H. Jackson and P. McGorry). Cambridge University Press: Cambridge; van Os J, Rutten BP, Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophrenia Bulletin 34:1066–1082, 2009.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jim van Os
    • 1
    • 2
  • Bart P.F. Rutten
    • 1
  • Richie Poulton
    • 3
  1. 1.Department of Psychiatry and NeuropsychologySchool of Mental Health and Neuroscience, Maastricht University Medical Centre, EURON, SEARCHMaastrichtThe Netherlands
  2. 2.Division of Psychological MedicineInstitute of PsychiatryLondonUK
  3. 3.Dunedin Multidisciplinary Health & Development Research Unit, Department of Preventive and Social MedicineDunedin School of Medicine, University of OtagoDunedinNew Zealand

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