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Progress in Genetic Studies of Schizophrenia

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Advances in Schizophrenia Research 2009

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Abstract

The current interpretation of the family and twin data suggest that most of the genetic risk to schizophrenia is conferred by multiple interacting loci, each causing a small increase in risk. As schizophrenia has similar symptoms and roughly similar prevalence throughout the world, a reasonable hypothesis is that at least some loci have effects in many populations. Until recently, there have been only a few undisputed genetic associations to complex non-Mendelian human diseases (for example, the HLA locus association to diabetes), but for many diseases, the advent of genome-wide association study (GWAS) technology has recently altered this situation. GWASs to date have focused on analyzing each individual marker of the 500,000 or more markers on the microarray and presenting the p-values in one large analysis, with statistical significance thresholds adjusted for the extensive multiple testing.

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Authors and Affiliations

  1. Centre for Addiction and Mental Health, Neurogenetics Section, M5T1R8, Toronto, ON, Canada

    Renan P. Souza

  2. Laboratorio de Neurociencias, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Marco A. Romano Silva

  3. Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada

    James L. Kennedy

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  1. Renan P. Souza
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  2. Marco A. Romano Silva
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  3. James L. Kennedy
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Correspondence to Renan P. Souza .

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  1. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Wagner F. Gattaz

  2. Fac. Medicina, Universidade de São Paulo, Rua Ovídio Pires Campos 785, Sao Paulo, 05403-903, Brazil

    Geraldo Busatto

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Souza, R.P., Romano Silva, M.A., Kennedy, J.L. (2010). Progress in Genetic Studies of Schizophrenia. In: Gattaz, W., Busatto, G. (eds) Advances in Schizophrenia Research 2009. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0913-8_12

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