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Pattern Recognition in Phagocytic Clearance of Altered Self

  • Yoshinobu Nakanishi
  • Peter M. Henson
  • Akiko Shiratsuchi
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 653)

Abstract

Cells that are unnecessary or harmful to our body emerge in substantial numbers throughout our life. Such “unwanted” cells need to be promptly and selectively removed for tissue homeostasis to be maintained. Most of those cells are induced to undergo physiologic cell death, i.e., apoptosis, and subsequently eliminated by phagocytosis. Target selectivity in this phagocytosis reaction comes from the specific cell-cell interaction between phagocytes and dying cells. The surface structure of apoptotic cells is altered during the death pathway so that they become pattern recognizable as “altered self” by phagocytes, and such surface structures are sometimes called ACAMPs for apoptotic cell-associated molecular patterns. ACAMPs arise either from the exofacial exposure of endogenous molecules or the modification of preexisting surface molecules. Pattern-recognizing phagocytosis receptors present at the surface of phagocytes specifically bind, either directly or indirectly with an aid of bridge molecules, to ACAMPs and transmit signals to induce phagocytosis of bound apoptotic cells. Phagocytes often evoke subsequent actions, rather than simply digesting engulfed apoptotic cells, for a finer tuning of tissue homeostasis. In contrast, precise mechanisms and consequences of cells undergoing nonapoptotic death, i.e., necrosis or autophagy-related death, are less well understood.

Keywords

Apoptotic Cell Outer Leaflet Cell Death Differ Phagocytic Clearance Physiologic Cell Death 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 1999; 17:593–623.CrossRefPubMedGoogle Scholar
  2. 2.
    Stuart LM, Ezekowitz RAB. Phagocytosis: Elegant complexity. Immunity 2005; 22:539–550.CrossRefPubMedGoogle Scholar
  3. 3.
    Taylor PR, Martinez-Pomares L, Stacey M et al. Macrophage receptors and immune recognition. Annu Rev Immunol 2005; 23:901–944.CrossRefPubMedGoogle Scholar
  4. 4.
    Underhill DM, Ozinsky A. Phagocytosis of microbes: Complexity in action. Annu Rev Immunol 2002; 20:825–852.CrossRefPubMedGoogle Scholar
  5. 5.
    Janeway CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20:197–216.CrossRefPubMedGoogle Scholar
  6. 6.
    Roos A, Xu W, Castellano G et al. A pivotal role for innate immunity in the clearance of apoptotic cells. Eur J Immunol 2004; 34:921–929.CrossRefPubMedGoogle Scholar
  7. 7.
    Gregory CD, Devitt A. The macrophage and the apoptotic cells: An innate immune interaction viewed simplistically? Immunology 2004; 113:1–14.CrossRefPubMedGoogle Scholar
  8. 8.
    Wyllie AH, Kerr JFR, Currie AR. Cell death: The significance of apoptosis. Int Rev Cytol 1980; 68:251–306.CrossRefPubMedGoogle Scholar
  9. 9.
    Franc NC, White K, Ezekowitz RAB. Phagocytosis and development: Back to the future. Curr Opin Immunol 1999; 11:47–52.CrossRefPubMedGoogle Scholar
  10. 10.
    Gregory CD. CD14-dependent clearance of apoptotic cells: Relevance to the immune system. Curr Opin Immunol 2000; 12:27–34.CrossRefPubMedGoogle Scholar
  11. 11.
    Lauber K, Blumenthal SG, Waibel M et al. Clearance of apoptotic cells: Getting rid of the corpse. Mol Cell 2004; 14:277–287.CrossRefPubMedGoogle Scholar
  12. 12.
    Zachowski A. Phospholipids in animal eukaryotic membranes: Transverse asymmetry and movement. Biochem J 1993; 294:1–14.PubMedGoogle Scholar
  13. 13.
    Zwaal RFA, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89:1121–1132.PubMedGoogle Scholar
  14. 14.
    Williamson P, Schlegel RA. Transbilayer phospholipid movement and the clearance of apoptotic cells. Biochim Biophys Acta 2002; 1585:53–63.PubMedGoogle Scholar
  15. 15.
    Fadok VA, Bratton DL, Frasch SC et al. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes. Cell Death Differ 1998; 5:551–562.CrossRefPubMedGoogle Scholar
  16. 16.
    Reddien PW, Horvitz HR. The engulfment process of programmed cell death in Caenorhabditis elegans. Annu Rev Cell Dev Biol 2004; 20:193–221.CrossRefPubMedGoogle Scholar
  17. 17.
    Manaka J, Kuraishi T, Shiratsuchi A et al. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. J Biol Chem 2004; 279:48466–48476.CrossRefPubMedGoogle Scholar
  18. 18.
    Gardai SJ, McPhillips KA, Frasch SC et al. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 2005; 123:321–334.CrossRefPubMedGoogle Scholar
  19. 19.
    Henson PM, Bratton DL, Fadok VA. Apoptotic cell removal. Curr Biol 2001; 11:R795–R805.CrossRefPubMedGoogle Scholar
  20. 20.
    Brown S, Heinisch I, Ross E et al. Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 2002; 418:200–203.CrossRefPubMedGoogle Scholar
  21. 21.
    Oldenborg PA, Gresham HD, Lindberg FP. CD47-signal regulatory protein α (SIRP α) regulates Fcγ and complement receptor-mediated phagocytosis. J Exp Med 2001; 193:855–861.CrossRefPubMedGoogle Scholar
  22. 22.
    Rosen A, Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 1999; 6:6–12.CrossRefPubMedGoogle Scholar
  23. 23.
    Ren Y, Savill J. Apoptosis: The importance of being eaten. Cell Death Differ 1998; 5:563–568.CrossRefPubMedGoogle Scholar
  24. 24.
    Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences. J Clin Invest 2001; 108:957–962.PubMedGoogle Scholar
  25. 25.
    Zong WX, Thompson CB. Necrotic death as a cell fate. Genes Dev 2006; 20:1–15.CrossRefPubMedGoogle Scholar
  26. 26.
    Baehrecke EH. Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 2005; 6:505–510.CrossRefPubMedGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Yoshinobu Nakanishi
    • 2
  • Peter M. Henson
    • 1
  • Akiko Shiratsuchi
    • 2
  1. 1.Department of Pediatrics Division of Cell BiologyNational Jewish Medical and Research CenterDenverUSA
  2. 2.Graduate School of Medical ScienceKanazawa UniversityIshikawaJapan

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