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Lung Surfactant Proteins A and D as Pattern Recognition Proteins

  • Patrick Waters
  • Mudit Vaid
  • Uday Kishore
  • Taruna Madan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 653)

Abstract

Lung surfactant proteins A and D belong to a group of soluble humoral pattern recognition receptors, called collectins, which modulate the immune response to microorganisms. They bind essential carbohydrate and lipid antigens found on the surface of microorganisms via low affinity C-type lectin domains and regulate the host’s response by binding to immune cell surface receptors. They form multimeric structures that bind, agglutinate, opsonise and neutralize many different pathogenic microorganisms including bacteria, yeast, fungi and viruses. They modulate the uptake of these microorganisms by phagocytic cells as well as both the inflammatory and the adaptive immune responses. Recent data have also highlighted their involvement in clearance of apoptotic cells, hypersensitivity and a number of lung diseases.

Keywords

Alveolar Macrophage Surfactant Protein Carbohydrate Recognition Domain Pulmonary Surfactant Protein Lung Surfactant Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Patrick Waters
    • 1
  • Mudit Vaid
    • 2
  • Uday Kishore
    • 3
  • Taruna Madan
    • 4
  1. 1.Neurosciences Group Department of Clinical Neurolog Weatherall Institute of Molecular MedicineJohn Radcliffe HospitalHeadington, OxfordUK
  2. 2.Department of DermatologyUniversity of AlabamaBirminghamUSA
  3. 3.Laboratory of Human Immunology and Infection Biology Biosciences Division School of Health Sciences and Social CareBrunei UniversityUxbridge, LondonUK
  4. 4.Department of Innate ImmunologyNational Institute for Research in Reproductive HealthMumbaiIndia

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