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Lung Surfactant Proteins A and D as Pattern Recognition Proteins

  • Chapter
Target Pattern Recognition in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 653))

Abstract

Lung surfactant proteins A and D belong to a group of soluble humoral pattern recognition receptors, called collectins, which modulate the immune response to microorganisms. They bind essential carbohydrate and lipid antigens found on the surface of microorganisms via low affinity C-type lectin domains and regulate the host’s response by binding to immune cell surface receptors. They form multimeric structures that bind, agglutinate, opsonise and neutralize many different pathogenic microorganisms including bacteria, yeast, fungi and viruses. They modulate the uptake of these microorganisms by phagocytic cells as well as both the inflammatory and the adaptive immune responses. Recent data have also highlighted their involvement in clearance of apoptotic cells, hypersensitivity and a number of lung diseases.

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Authors and Affiliations

  1. Neurosciences Group Department of Clinical Neurolog Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK

    Patrick Waters

  2. Department of Dermatology, University of Alabama, Birmingham, Alabama, USA

    Mudit Vaid

  3. Laboratory of Human Immunology and Infection Biology Biosciences Division School of Health Sciences and Social Care, Brunei University, Uxbridge, London, UK

    Uday Kishore

  4. Department of Innate Immunology, National Institute for Research in Reproductive Health, Mumbai, India

    Taruna Madan

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  1. Patrick Waters
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  2. Mudit Vaid
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  4. Taruna Madan
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Editors and Affiliations

  1. Laboratory of Human Immunology and Infection Biology, Biosciences Division, School of Health Sciences and Social Care, Brunei University, Uxbridge, London, UK

    Uday Kishore PhD

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Waters, P., Vaid, M., Kishore, U., Madan, T. (2009). Lung Surfactant Proteins A and D as Pattern Recognition Proteins. In: Kishore, U. (eds) Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, vol 653. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0901-5_6

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