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NOD-Like Receptors—Pivotal Guardians of the Immunological Integrity of Barrier Organs

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Target Pattern Recognition in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 653))

Abstract

NOD-like receptors (NLRs) exert pivotal roles in innate immunity as sensors of exogenous or endogenous cellular danger signals. The NLR protein family has a characteristic domain architecture comprising a central nucleotide binding and oligomerization domain (NOD), an N-terminal effector binding domain and C-terminal leucine-rich repeats (LRRs). Mutations in NLR genes are genetically associated with a number of chronic inflammatory diseases of barrier organs. In this chapter, we focus on the influence of NLR regulation and function in the complex pathophysiology of mucosal homeostasis. The understanding of NLR biology may guide our future understanding of how the interaction between the human genome and the metagenome of transient and resident microbiota precipitates into chronic inflammatory disorders, such as Crohn’s disease or atopy.

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Authors and Affiliations

  1. Institute for Clinical Molecular Biology, 1st Department of Medicine, University Hospital Schleswig-Holstein Campus Kiel, Schittenhelmstr.12, 24105, Kiel, Germany

    Stefan Schreiber

  2. Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany

    Philip Rosenstiel

  3. Max-Planck Institute for Molecular Genetics, Berlin, Germany

    Philip Rosenstiel

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  1. Philip Rosenstiel
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  2. Stefan Schreiber
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Editors and Affiliations

  1. Laboratory of Human Immunology and Infection Biology, Biosciences Division, School of Health Sciences and Social Care, Brunei University, Uxbridge, London, UK

    Uday Kishore PhD

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Rosenstiel, P., Schreiber, S. (2009). NOD-Like Receptors—Pivotal Guardians of the Immunological Integrity of Barrier Organs. In: Kishore, U. (eds) Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, vol 653. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0901-5_3

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