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Structural Basis of Pattern Recognition by Innate Immune Molecules

  • Eamon P. McGreal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 653)

Abstract

The importance of the innate immune system as a first line defence against pathogenic challenge has long been recognised. Over the last decade the identity of many of the key molecules mediating innate host defence have been clarified and a model of self/ nonself discrimination by families of pattern recognition receptors (PRRs) has emerged. Although a large amount of information is now available concerning the action of these innate immune molecules at the level of the cell and organism, litde is known about the molecular interface between pathogens and innate immune recognition molecules. In this chapter the molecular basis for innate immune discrimination of a wide variety of pathogen derived molecules is discussed in the context of the emerging literature.

Keywords

Ligand Binding Innate Immune System Innate Host Defence Macrophage Mannose Receptor Pattern Recognition Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Eamon P. McGreal
    • 1
  1. 1.Department of Child HealthCardiff University School of MedicineHeath Park, CardiffUK

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