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Cardiothoracic Surgery in the Elderly pp 453–460Cite as

Heart Transplantation and Mechanical Assistance in the Elderly

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Abstract

Heart failure is a major source of morbidity and mortality in the population 65 and older. While medications offer benefit, many patients progress to end-stage heart failure. Heart transplantation and mechanical assistance offer the hope of improved quality and length of life in patients with end-stage heart failure.

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References

  1. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. Focused update incorporated into the ACC/AHA 2005 Guidelines for the diagnosis and management of heart failure in adults a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration with the International Society for Heart and Lung Transplantation. J Am Coll Cardiol. 2009;53(15):e1–90.

    Article  PubMed  Google Scholar 

  2. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart Disease and Stroke Statistics – 2010 Update. A Report From the American Heart Association. Circulation. 2009.

    Google Scholar 

  3. Konstam MA, Rousseau MF, Kronenberg MW, Udelson JE, Melin J, Stewart D, et al. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators. Circulation. 1992;86(2):431–8.

    Article  PubMed  CAS  Google Scholar 

  4. Packer M, Poole-Wilson PA, Armstrong PW, Cleland JG, Horowitz JD, Massie BM, et al. Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group. Circulation. 1999;100(23):2312–8.

    Article  PubMed  CAS  Google Scholar 

  5. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet. 2003;362(9377):7–13.

    Article  PubMed  CAS  Google Scholar 

  6. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140–50.

    Article  PubMed  CAS  Google Scholar 

  7. Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, et al. The Seattle heart failure model: prediction of survival in heart failure. Circulation. 2006;113(11):1424–33.

    Article  PubMed  Google Scholar 

  8. Hershberger RE, Nauman D, Walker TL, Dutton D, Burgess D. Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure. J Card Fail. 2003;9(3):180–7.

    Article  PubMed  Google Scholar 

  9. Gorodeski EZ, Chu EC, Reese JR, Shishehbor MH, Hsich E, Starling RC. Prognosis on chronic dobutamine or milrinone infusions for stage D heart failure. Circ Heart Fail. 2009;2(4):320–4.

    Article  PubMed  CAS  Google Scholar 

  10. Taylor DO, Stehlik J, Edwards LB, Aurora P, Christie JD, Dobbels F, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. J Heart Lung Transplant. 2009;28(10):1007–22.

    Article  PubMed  Google Scholar 

  11. Marelli D, Kobashigawa J, Hamilton MA, Moriguchi JD, Kermani R, Ardehali A, et al. Long-term outcomes of heart transplantation in older recipients. J Heart Lung Transplant. 2008;27(8):830–4.

    Article  PubMed  Google Scholar 

  12. Tjang YS, van der Heijden GJ, Tenderich G, Korfer R, Grobbee DE. Impact of recipient’s age on heart transplantation outcome. Ann Thorac Surg. 2008;85(6):2051–5.

    Article  PubMed  Google Scholar 

  13. Blanche C, Blanche DA, Kearney B, Sandhu M, Czer LS, Kamlot A, et al. Heart transplantation in patients seventy years of age and older: a comparative analysis of outcome. J Thorac Cardiovasc Surg. 2001;121(3):532–41.

    Article  PubMed  CAS  Google Scholar 

  14. Demers P, Moffatt S, Oyer PE, Hunt SA, Reitz BA, Robbins RC. Long-term results of heart transplantation in patients older than 60 years. J Thorac Cardiovasc Surg. 2003;126(1):224–31.

    Article  PubMed  Google Scholar 

  15. Laks H, Scholl FG, Drinkwater DC, Blitz A, Hamilton M, Moriguchi J, et al. The alternate recipient list for heart transplantation: does it work? J Heart Lung Transplant. 1997;16(7):735–42.

    PubMed  CAS  Google Scholar 

  16. Felker GM, Milano CA, Yager JE, Hernandez AF, Blue L, Higginbotham MB, et al. Outcomes with an alternate list strategy for heart transplantation. J Heart Lung Transplant. 2005;24(11):1781–6.

    Article  PubMed  Google Scholar 

  17. Chen JM, Russo MJ, Hammond KM, Mancini DM, Kherani AR, Fal JM, et al. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann Thorac Surg. 2005;80(1):224–8.

    Article  PubMed  Google Scholar 

  18. Nativi JN, Kfoury AG, Myrick C, Peters M, Renlund D, Gilbert EM, et al. Effects of the 2006 U.S. thoracic organ allocation change: analysis of local impact on organ procurement and heart transplantation. J Heart Lung Transplant. 2009.

    Google Scholar 

  19. Miller LW, Pagani FD, Russell SD, John R, Boyle AJ, Aaronson KD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357(9):885–96.

    Article  PubMed  CAS  Google Scholar 

  20. Pagani FD, Miller LW, Russell SD, Aaronson KD, John R, Boyle AJ, et al. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54(4):312–21.

    Article  PubMed  Google Scholar 

  21. Holman WL, Kormos RL, Naftel DC, Miller MA, Pagani FD, Blume E, et al. Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study. J Heart Lung Transplant. 2009;28(1):44–50.

    Article  PubMed  Google Scholar 

  22. Kirklin JK, Naftel DC, Kormos RL, Stevenson LW, Pagani FD, Miller MA, et al. Second INTERMACS annual report: more than 1, 000 primary left ventricular assist device implants. J Heart Lung Transplant. 2010;29(1):1–10.

    Article  PubMed  Google Scholar 

  23. Frazier OH. Michael E. DeBakey, 1908 to 2008. J Thorac Cardiovasc Surg. 2008;136(4):809–11.

    Article  PubMed  CAS  Google Scholar 

  24. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med. 2001;345(20):1435–43.

    Article  PubMed  CAS  Google Scholar 

  25. Pagani FD, Long JW, Dembitsky WP, Joyce LD, Miller LW. Improved mechanical reliability of the HeartMate XVE left ventricular assist system. Ann Thorac Surg. 2006;82(4):1413–8.

    Article  PubMed  Google Scholar 

  26. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361(23):2241–51.

    Article  PubMed  CAS  Google Scholar 

  27. Russell SD, Rogers JG, Milano CA, Dyke DB, Pagani FD, Aranda JM, et al. Renal and hepatic function improve in advanced heart failure patients during continuous-flow support with the HeartMate II left ventricular assist device. Circulation. 2009;120(23):2352–7.

    Article  PubMed  Google Scholar 

  28. Friedel N, Viazis P, Schiessler A, Warnecke H, Hennig E, Trittin A, et al. Recovery of end-organ failure during mechanical circulatory support. Eur J Cardiothorac Surg. 1992;6(10):519–22; discussion 523.

    Google Scholar 

  29. Lietz K, Long JW, Kfoury AG, Slaughter MS, Silver MA, Milano CA, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation. 2007;116(5):497–505.

    Article  PubMed  Google Scholar 

  30. Miller LW, Lietz K. Candidate selection for long-term left ventricular assist device therapy for refractory heart failure. J Heart Lung Transplant. 2006;25(7):756–64.

    Article  PubMed  Google Scholar 

  31. Gregoric ID, La Francesca S, Myers T, Cohn W, Loyalka P, Kar B, et al. A less invasive approach to axial flow pump insertion. J Heart Lung Transplant. 2008;27(4):423–6.

    Article  PubMed  Google Scholar 

  32. Slaughter MS, Sobieski MA, 2nd, Tamez D, Horrell T, Graham J, Pappas PS, et al. HeartWare miniature axial-flow ventricular assist device: design and initial feasibility test. Tex Heart Inst J. 2009;36(1):12–6.

    PubMed  Google Scholar 

  33. Griffith K, Jenkins E, Pagani FD. First American experience with the Terumo DuraHeart left ventricular assist system. Perfusion. 2009;24(2):83–9.

    Article  PubMed  CAS  Google Scholar 

  34. Pitsis AA, Visouli AN, Ninios V, Bougioukas G, Filippatos G, Kremastinos D, et al. Elective bridging to recovery after repair: the surgical approach to ventricular reverse remodeling. Artif Organs. 2008;32(9):730–5.

    Article  PubMed  Google Scholar 

  35. Kirklin J, Young J, McGiffin D. Heart transplantation. Philadelphia: Churchill Livingstone; 2002. p. 217.

    Google Scholar 

  36. Sellke FW, del Nido PJ, MD, Swanson SJ, editors. Sabiston and Spencer surgery of the chest. 8th ed. Vol. 2, Philadelphia: Saunders; 2010. p. 1539.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiac Surgery, Northwestern Memorial Hospital, Bluhm Cardiovascular Institue, Chicago, IL, 60611, USA

    Edwin C. McGee Jr.

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  1. Edwin C. McGee Jr.
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Correspondence to Edwin C. McGee Jr. .

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Editors and Affiliations

  1. , Department of Thoracic Surgery, Geisinger Wyoming Valley Medical Center, 1000 East Mountain Drive, Wilkes-Barre, 18711, Pennsylvania, USA

    Mark R. Katlic

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McGee, E.C. (2011). Heart Transplantation and Mechanical Assistance in the Elderly. In: Katlic, M. (eds) Cardiothoracic Surgery in the Elderly. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0892-6_36

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  • DOI: https://doi.org/10.1007/978-1-4419-0892-6_36

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0891-9

  • Online ISBN: 978-1-4419-0892-6

  • eBook Packages: MedicineMedicine (R0)

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