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Endocrine Neoplasia pp 287–302Cite as

Multiple Endocrine Neoplasia Type 1: Clinical Manifestations and Management

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Part of the book series: Cancer Treatment and Research ((CTAR,volume 153))

Abstract

Multiple endocrine neoplasia type I (MEN-1) is an autosomal dominant syndrome associated with anterior pituitary, parathyroid, and enteropancreatic endocrine tumors as well as other endocrine and nonendocrine tumors [1]. MEN-1 is defined as the presence of two of three main MEN-1-related manifestations, or at least one manifestation plus a first degree relative with at least one MEN-1-related manifestation [1,2]. The estimated prevalence of MEN-1 ranges from 1 in 10,000 to 1 in 100,000 [3], with 43 and 94% penetrance of MEN-1 by ages 20 and 50, respectively [4].

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Authors and Affiliations

  1. Tumor Angiogenesis Section, Surgery Branch, National Cancer Institute, Bethesda, MD, USA

    Anathea C. Powell (Clinical Fellow)

  2. Department of Surgery, Director, Montefiore-Einstein Center for Cancer Care., Bronx, NY, USA

    Steven K. Libutti (Professor of Surgery, Vice Chairman)

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  1. Anathea C. Powell
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Correspondence to Steven K. Libutti .

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  1. Feinberg School of Medicine, Northwestern University, E. Huron St. 201, Chicago, 60611, U.S.A.

    Cord Sturgeon

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Powell, A.C., Libutti, S.K. (2010). Multiple Endocrine Neoplasia Type 1: Clinical Manifestations and Management. In: Sturgeon, C. (eds) Endocrine Neoplasia. Cancer Treatment and Research, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0857-5_16

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