Narcolepsy pp 167-178 | Cite as

Hypersomnias Other than Narcolepsy: Differential Diagnosis

Chapter

Abstract

Although narcolepsy can be viewed as a key hypersomnia in relation to its severity and the light it sheds on the whole field of sleep due to its special clinical, polysomnographic, pharmacological and neurochemical, immunogenetic and hypocretinergic features, it is not by far the most frequent hypersomnia. Diagnosing other hypersomnias is a matter of clinical reasoning leading to a clinical impression, sufficient by itself or orienting towards various laboratory tests. This review will cover five different groups of hypersomnia: hypersomnia as a direct consequence of a behaviour or of the use of a drug or substance, hypersomnia as a consequence of a sleep-related breathing disorder, hypersomnia of central origin other than narcolepsy, hypersomnia associated with various medical disorders and hypersomnia not due to substance or known physiological condition (psychiatric hypersomnia). For all these conditions clinical and laboratory tests will be reviewed, as well as the present state of knowledge in terms of pathophysiology. In addition, the issue of periodic limb movements in sleep and excessive daytime sleepiness will be discussed.

Keywords

Behaviorally induced insufficient sleep syndrome Hypersomnia due to drug or substance Idiopathic hypersomnia Recurrent hypersomnia Hypersomnia due to medical condition Hypersomnia not due to substance or known physiological condition 

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of NeurologyGui de Chauliac HospitalMontpellier Cedex 5France

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