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Cell-Extracellular Matrix Interactions in Cancer pp 191–215Cite as

Proteoglycans and Cancer

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Abstract

Proteoglycans are ubiquitous molecules composed of glycosamino-glycan chains attached covalently to core proteins. Proteoglycans perform a myriad of functions and participate in regulating tumor cell growth, survival, adhesion, metastasis and angiogenesis. These functions are largely mediated through inter-actions between their charged glycosaminoglycan chains and effector proteins such as growth factors, cytokines and chemokines. In addition, emerging data is revealing that the core proteins of proteoglycans can also form complexes with other proteins such as integrins and regulate their signaling. Because proteoglycans are at the crossroads of many signaling events, they are currently being extensively investigated for their potential as therapeutic targets for cancer. This review focuses on the expression, structure and function of proteoglycans in cancer and provides an overview of the field as well as specific examples of how these diverse molecules regulate tumor behavior.

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Acknowledgments

Support to the authors includes grants from the National Institutes of Health CA135075 and CA055819 (to RDS), Institutional Training Fellowship T32 AR047512 (to JR), the Veterans Administration (to RDS), and the Multiple Myeloma Research Foundation (to YY). We apologize to authors whose work was not cited because of space limitations.

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  1. Department of Pathology, University of Alabama at Birmingham, 814 SHEL, 1530 Third Avenue South, Birmingham, AL, 35294, USA

    Ralph D. Sanderson

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  1. Ralph D. Sanderson
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  2. Yang Yang
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Correspondence to Ralph D. Sanderson .

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  1. Vanderbilt University Medical Center, Department of Medicine, Nashville, 37232, U.S.A.

    Roy Zent

  2. Medical Center, Vanderbilt University, Nashville, 37232, U.S.A.

    Ambra Pozzi

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Sanderson, R.D., Yang, Y., Purushothaman, A., Khotskaya, Y.B., Ritchie, J.P., Ramani, V.C. (2010). Proteoglycans and Cancer. In: Zent, R., Pozzi, A. (eds) Cell-Extracellular Matrix Interactions in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0814-8_9

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