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Cell-Extracellular Matrix Interactions in Cancer pp 1–17Cite as

The Extracellular Matrix: An Overview

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Abstract

The extracellular matrix encompasses the very large number of constituent macromolecules that are synthesized and secreted by cells into the space surrounding them, followed in most cases by further assembly, cross-linking, and/or polymerization of the secreted proteins to form an organized structure. The extracellular matrix has a number of critical roles in tissue and organ development, function, and repair after injury. In addition, there are numerous serious and debilitating genetic diseases whose bases lie in mutations in genes encoding extracellular matrix proteins. There are also acquired diseases, such as scurvy, chronic obstructive pulmonary disease, and cancer, that can be caused by damage to or are influenced by changes in the organization or integrity of the extracellular matrix. The goal of this chapter is to provide an overview of the extracellular matrix by discussing the different classes of extracellular matrix molecules and presenting a subset of individual extracellular matrix proteins from each class in greater detail in order to demonstrate their importance.

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Acknowledgments

This work was supported by R01DK078314 and R01GM060432 (both to JHM).

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Authors and Affiliations

  1. Renal Division, Washington University School of Medicine, 660 S. Euclid Ave, 8126, St. Louis, MO, 63110, USA

    Jeffrey H. Miner

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  1. Jeffrey H. Miner
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Correspondence to Jeffrey H. Miner .

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Editors and Affiliations

  1. Vanderbilt University Medical Center, Department of Medicine, Nashville, 37232, U.S.A.

    Roy Zent

  2. Medical Center, Vanderbilt University, Nashville, 37232, U.S.A.

    Ambra Pozzi

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Miner, J.H. (2010). The Extracellular Matrix: An Overview. In: Zent, R., Pozzi, A. (eds) Cell-Extracellular Matrix Interactions in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0814-8_1

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