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HIV Co-receptors: The Brain Perspective

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Book cover Chemokine Receptors and NeuroAIDS

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Abstract

Chemokines and chemokine receptors are significant to the establishment and maintenance of HIV-1 infection, viral transmission, and AIDS pathogenesis. They also play an important role in the development of neurologic complications of AIDS, including HIV-1-associated dementia (HIVD), through several mechanisms. The contribution of chemokines to the development of AIDS and HIVD is complex; some chemokines appear to aid pathogenesis, while others appear to be protective. In the following chapter, we discuss the role of chemokines and chemokine receptors in HIV-1 infection and the pathogenesis of AIDS and HIVD. Potential therapeutic strategies are also briefly detailed.

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  1. Department of Neuroscience, Temple University School of Medicine, 1900 N. 12th St., Biology Life Science Bldg., Rm. 246, Philadelphia, PA, 19122, USA

    Tracy Fischer-Smith & Jay Rappaport

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  1. Tracy Fischer-Smith
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  2. Jay Rappaport
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Correspondence to Jay Rappaport .

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  1. Dept. Pharmacology & Physiology, & Institute of Molecular Medicine, Drexel University College of Medicine, North 15th St. 245, Philadelphia, 19102-1101, USA

    Olimpia Meucci

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Fischer-Smith, T., Rappaport, J. (2010). HIV Co-receptors: The Brain Perspective. In: Meucci, O. (eds) Chemokine Receptors and NeuroAIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0793-6_3

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