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Sentinel Node Biopsy in Oral Cancer

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Oral Cancer Metastasis

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Abstract

In patients with cT1-T2 oral/oropharyngeal squamous cell cancer, involve­ment of the cervical lymph nodes is associated with a 50% decrease in 5-year survival and represents the most important prognostic factor in this patient group. Precise staging of the cervical nodes is therefore of utmost importance, to ensure an accurate prognosis and provision of the most appropriate treatment.

The gold standard for staging the cervical nodes is elective neck dissection, providing both diagnostic and therapeutic measures. However, only one-fourth of cT1-T2 patients are found to harbor occult nodal disease, and the remainder of patients may be unnecessarily exposed to the considerable morbidity associated with neck dissection.

The sentinel node biopsy procedure provides a means of obtaining tissue for pathological staging of the cervical lymph node basin, while potentially avoiding the morbidity of an elective neck dissection. This chapter describes the technique, its accuracy and current applications, and its potential role in the management of patients with early oral/oropharyngeal squamous cell cancer.

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  1. Plastic Surgery department, Christie Hospital, Wilmslow, M20 4BX, UK

    G. L. Ross

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  1. L. W. T. Alkureishi
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Correspondence to G. L. Ross .

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  1. M D Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030-4009, U.S.A.

    Jeffrey Myers

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Alkureishi, L.W.T., Ross, G.L., Stoeckli, S.J. (2009). Sentinel Node Biopsy in Oral Cancer. In: Myers, J. (eds) Oral Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0775-2_3

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