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Oral Cancer Metastasis pp 287–298Cite as

Chemokines and Their Receptors in Oral Cancer Metastasis

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Abstract

In oral cancers, a high degree of local invasion and metastases to the regional cervical lymph nodes is observed. Distant metastases occur at a low rate and are rarely observed until late in the disease. The underlying mechanism(s) of this site-specific metastasis has been the subject of numerous studies. Chemokine receptors have been described as being important in the metastatic process of these tumors given that the lymph nodes, which represent a key site of metastasis, also happen to be an abundant source of the chemokine ligands for oral cancer tumor-associated chemokine receptors. We review our current understanding of the role that chemokines, and their receptors play in the dissemination of metastatic disease in oral cancers while highlighting their importance to the overall survival and migratory ability of these tumors. Ongoing advances in our knowledge of cell migration and tumor metastasis continue to present opportunities for the development of prognostic markers and therapeutic intervention.

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Author information

Authors and Affiliations

  1. Hillman Cancer Center, Research Pavilion 1.19d, Pittsburgh, PA, 15213, USA

    Robert L. Ferris

Authors
  1. Yvonne K. Mburu
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  2. Robert L. Ferris
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Correspondence to Robert L. Ferris .

Editor information

Editors and Affiliations

  1. M D Anderson Cancer Center, University of Texas, Holcombe Blvd. 1515, Houston, 77030-4009, U.S.A.

    Jeffrey Myers

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Mburu, Y.K., Ferris, R.L. (2009). Chemokines and Their Receptors in Oral Cancer Metastasis. In: Myers, J. (eds) Oral Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0775-2_13

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