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Immunologic Mechanisms in Lung Carcinogenesis and Metastasis

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Abstract

Progression and metastasis of cancer proceeds in the context of a host response that includes interactions with immune cells that can both attenuate and paradoxically promote the process of metastasis. Growing evidence demonstrating the role of the inflammatory response in carcinogenesis is shedding light on a functional relationship between the host immune system and the malignant neoplasm. The interaction between neoplasm and the immune system can be described with the concepts of (1) cancer immunosurveillance, (2) cancer immunoediting, (3) complicity of the host cellular networks in lung tumorigenesis, and (4) tumor-mediated immunosuppression. Understanding the molecular mechanisms involved in inflammation and lung carcinogenesis provides insight for new drug development that target reversible, non-mutational events in the chemoprevention and treatment of lung cancer.

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Authors and Affiliations

  1. Division of Cardiothoracic Surgery, Department of Surgery, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA

    Jay M. Lee & Sherven Sharma

  2. Division of Pulmonary and Critical Care Medicine and Hospitalists, Department of Medicine, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA

    Jane Yanagawa, Saswati Hazra, Tonya Walser & Steven M. Dubinett

  3. Division of Hematology and Oncology, Department of Medicine, UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA

    Edward Garon

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  1. Dept. Internal Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, U.S.A.

    Venkateshwar Keshamouni

  2. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Douglas Arenberg

  3. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Gregory Kalemkerian

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Lee, J.M. et al. (2009). Immunologic Mechanisms in Lung Carcinogenesis and Metastasis. In: Keshamouni, V., Arenberg, D., Kalemkerian, G. (eds) Lung Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0772-1_6

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