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Lung Cancer Metastasis pp 267–287Cite as

Molecular Imaging in Lung Cancer Metastases

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Abstract

Advances in gene profiling technology have led to the identification of novel gene expression signatures and individual biomarkers associated with the cancer and the spread of malignancy to distant organs. Molecular imaging is a very promising technology which provides the potential for utilizing these biomarkers for monitoring tumor progression and therapeutic response. This technology may allow real-time, dynamic, and quantifiable monitoring of biomarker activity. This chapter describes molecular imaging modalities that are currently available for monitoring clinical and experimental metastasis, their application and potential to monitor tumor progression and therapeutic outcome of a treatment regimen in real time, and in the discovery and development of novel drugs that target metastatic disease.

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Acknowledgments

We thank Terry Williams for critical reading of the manuscript. This work was supported by US National Institutes of Health grants P01CA85878, P50CA01014, R24CA83099, R01RCA129623A and a grant from the John and Suzanne Munn Endowed Research Fund of the University of Michigan Comprehensive Cancer Center (to MSB).

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Authors and Affiliations

  1. Departments of Radiation Oncology, University of Michigan, 48109, Ann Arbor, MI, USA

    Mahaveer Swaroop Bhojani

  2. Center for Molecular Imaging, Departments of Radiation Oncology and Radiology, University of Michigan, 48109, Ann Arbor, MI, USA

    Shyam Nyati, Hyma R. Rao, Brian D. Ross PhD & Alnawaz Rehemtulla

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  1. Mahaveer Swaroop Bhojani
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  2. Shyam Nyati
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  5. Alnawaz Rehemtulla
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Correspondence to Mahaveer Swaroop Bhojani .

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  1. Dept. Internal Medicine, University of Michigan Health System, Zina Pitcher Place 109, Ann Arbor, 48109-2200, U.S.A.

    Venkateshwar Keshamouni

  2. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Douglas Arenberg

  3. Dept. Internal Medicine, University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109, U.S.A.

    Gregory Kalemkerian

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Bhojani, M.S., Nyati, S., Rao, H.R., Ross, B.D., Rehemtulla, A. (2009). Molecular Imaging in Lung Cancer Metastases. In: Keshamouni, V., Arenberg, D., Kalemkerian, G. (eds) Lung Cancer Metastasis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0772-1_13

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