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Visual Prosthetics pp 159–172Cite as

Retinal Cell Excitation Modeling

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Abstract

As the electrode density of implantable retinal prosthesis increases, simulation becomes a valuable tool to characterize excitation performance, evaluate implant electrical safety, determine optimal geometry and placement of implant current return, and understand charge distribution due to stimulation. To gain an insight into the effectiveness of a retina stimulator, quasi-static numerical electromagnetic methods can help estimate current densities, potentials, and their gradients in retinal layers and neural cells. Detailed discrete three-dimensional models of the retina, implant and surrounding tissue can be developed to account for the anatomical complexity of the human eye and appropriate dielectric properties. This chapter will cover the basics of quasi-static methods that can be used for this purpose. Specifically, authors will focus on the admittance method, the output it produces, and possibilities it offers to determine the potential effectiveness of a retinal stimulator, ranging from evaluating the current density magnitude in the ganglion cell layer, to calculating local activation function in the areas targeted by the electrical stimulation.

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Abbreviations

GCL:

Ganglion cell layer

NFL:

Nerve fiber layer

SAR:

Specific absorption rate

References

  1. Armitage DW, LeVeen HH, Pethig R (1983), Radiofrequency-induced hyperthermia: computer simulation of specific absorption rate distributions using realistic anatomical models. Phys Med Biol, 28(1): p. 31–42.

    Article  Google Scholar 

  2. Brummer SB, Roblee LS (1983), Criteria for selecting electrodes for electrical stimulation: Theoretical and practical considerations. Ann NY Acad Sci, 405: p. 159–171.

    Article  Google Scholar 

  3. Ebert M, Brown PK, Lazzi G (2003), Two-dimensional SPICE-linked multiresolution impedance method for low frequency electromagnetic interactions. IEEE Trans Biomed Eng, 50(7): p. 881–889.

    Article  Google Scholar 

  4. Gabriel S, Lau RW, Gabriel C (1996), The dielectric properties of biological tissues: II Measurements in the frequency range 10 Hz to 20 GHz. Phys Med Biol, 41(11): p. 2251–2269.

    Article  Google Scholar 

  5. Gandhi OP, DeFord JF, Kanai H (1984), Impedance method for calculation of power deposition patterns in magnetically induced hyperthermia. IEEE Trans Biomed Eng, BME-31: p. 644–651.

    Article  Google Scholar 

  6. Greenberg RJ, Velte TJ, Humayun MS, et al. (1999), A computational model of electrical stimulation of the retinal ganglion cell. IEEE Trans Biomed Eng, 46(5): p. 505–514.

    Article  Google Scholar 

  7. Hodgkin AL, Huxley AF (1952), A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol, 117(4): p. 500–544.

    Google Scholar 

  8. Humayun MS, De Juan Jr E, Weiland JD, et al. (1999), Pattern electrical stimulation of the human retina. Vision Res, 39: p. 2569–2576.

    Article  Google Scholar 

  9. IEEE International Committee on Electromagnetic Safety (2005), IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields, 3 kHz to 300 GHz. IEEE Std C95.1.

    Google Scholar 

  10. International Commission for Non-Ionizing Radiation Protection (1998), Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health Phys 74: p. 494–522.

    Google Scholar 

  11. Karwoski CJ, Frambach DA, Proenza LM (1985), Laminar profile of resistivity in frog retina. J Neurophysiol 54(6): p. 1607–1619.

    Google Scholar 

  12. Mahadevappa M, Weiland JD, Yanai D, et al. (2005), Perceptual thresholds and electrode impedance in three retinal prostheses subjects. IEEE Trans Neural Syst Rehabil Eng, 13(2): p. 201–206.

    Article  Google Scholar 

  13. Rattay F (1986), Analysis of models for external stimulation of axons. IEEE Trans Biomed Eng, BME-33: p. 974–978.

    Article  Google Scholar 

  14. Rattay F (1989), Analysis of models for extracellular fiber stimulation. IEEE Trans Biomed Eng, BME-36(7): p. 676–682.

    Article  Google Scholar 

  15. Rattay F (1991), Electrical Nerve Stimulation: Theory, Experiments and Applications. Springer, New York.

    Google Scholar 

  16. Rodieck RW (1988), The primate retina. Comp Primate Biol, 4: p. 203–278.

    Google Scholar 

  17. Schmidt S, Cela CJ, Singh V, et al. (2007), Computational modeling of electromagnetic and thermal effects for a dual-unit retinal prosthesis: inductive telemetry, temperature increase, and current densities in the retina. Artificial Sight, eds. Humayun MS, Weiland JD, Chader G, et al.: Springer, Berlin.

    Google Scholar 

  18. Cela CJ (2010), A Multiresolution Admittance Method for Large-Scale Bioelectromagnetic Interactions. PhD dissertation, North Carolina State University, Raleigh, NC.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Electrical and Computer Engineering, University of Utah, 50 S. Central Campus Drive, Room 3280, Salt Lake City, UT, 84112-9206, USA

    Carlos J. Cela

Authors
  1. Carlos J. Cela
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  2. Gianluca Lazzi
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Corresponding author

Correspondence to Carlos J. Cela .

Editor information

Editors and Affiliations

  1. , Lions Vision Research & Rehabilitation C, Johns Hopkins University School of Medic, 550 N. Broadway, Baltimore, 21205-2020, Maryland, USA

    Gislin Dagnelie

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Cela, C.J., Lazzi, G. (2011). Retinal Cell Excitation Modeling. In: Dagnelie, G. (eds) Visual Prosthetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0754-7_8

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  • DOI: https://doi.org/10.1007/978-1-4419-0754-7_8

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0753-0

  • Online ISBN: 978-1-4419-0754-7

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