Abstract
This chapter provides a description of how microelectrodes are used to form an artificial interface to the cortex. Microelectrodes inserted into the cortex are called “intracortical electrodes” and are anticipated for use in cortical visual prostheses. Owing to the nature of the cortical environment, the design and use of these electrodes pose challenges for the clinical deployment of cortical prostheses. The combined effects of electrode charge injection and effects of the in vivo environment are discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- Ag|AgCl:
-
Silver–silver chloride
- AIROF:
-
Activated iridium oxide film
- C:
-
Capacitance
- CSC:
-
Charge storage capacity
- CSCA :
-
Anodic charge storage capacity
- CSCC :
-
Cathodic charge storage capacity
- CV:
-
Cyclic voltammetry
- I:
-
Current
- Ir:
-
Iridium
- IR:
-
Infrared
- PEDOT:
-
Polyethylenedioxythiophene
- Pt:
-
Platinum
- R:
-
Resistance
- Redox:
-
Reduction-oxidation chemical reaction
- SIROF:
-
Sputtered iridium oxide film
- V:
-
Voltage
References
Agnew WF, McCreery DB (1990), Considerations for safety with chronically implanted nerve electrodes. Epilepsia, 31(2): p. S27–32.
Agnew WF, Yuen TG, McCreery DB, Bullara LA (1986), Histopathologic evaluation of prolonged intracortical electrical stimulation. Exp Neurol, 92(1): p. 162–85.
Anderson DJ, Najafi K, Tanghe SJ, et al. (1989), Batch-fabricated thin-film electrodes for stimulation of the central auditory system. IEEE Trans Biomed Eng, 36(7): p. 693–704.
Bak M, Girvin JP, Hambrecht FT, et al. (1990), Visual sensations produced by intracortical microstimulation of the human occipital cortex. Med Biol Eng Comput, 28(3): p. 257–9.
Banerjee S, Kahn MG, Wong SS (2003), Rational chemical strategies for carbon nanotube functionalization. Chemistry, 9(9): p. 1898–908.
Beebe X, Rose TL (1988), Charge injection limits of activated iridium oxide electrodes with 0.2 ms pulses in bicarbonate buffered saline. IEEE Trans Biomed Eng, 35(6): p. 494–5.
Brindley G, Lewin W (1968), The sensations produced by electrical stimulation of the visual cortex. J Physiol, 196: p. 479–93.
Brummer SB, Robblee LS, Hambrecht FT (1983), Criteria for selecting electrodes for electrical stimulation: Theoretical and practical considerations. Ann NY Acad Sci, 405: p. 159–71.
Brummer SB, Turner MJ (1977), Electrochemical considerations for safe electrical stimulation of the nervous system with platinum electrodes. IEEE Trans Biomed Eng, 24(1): p. 59–63.
Buckely DN, Burke LD (1975), The oxygen electrode part 5 – Enhancement of charge capacity of an iridium surface in the anodic region. J Chem Soc Faraday Trans, 71: p. 1447–459.
Burke LD, Scannell RA (1984), An investigation of hydrous oxide growth on iridium in base. J Electroanal Chem, 175: p. 119–41.
Cogan SF (2006), In vivo and in vitro differences in the charge-injection and electrochemical properties of iridium oxide electrodes. Conf Proc IEEE Eng Med Biol Soc, 1: p. 882–5.
Cogan SF (2008), Neural stimulation and recording electrodes. Annu Rev Biomed Eng, 10: p. 275–309.
Cogan SF, Guzelian AA, Agnew WF, et al. (2004), Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation. J Neurosci Methods, 137(2): p. 141–50.
Cogan SF, Plante TD, Ehrlich J (2004), Sputtered iridium oxide films (SIROFs) for low-impedance neural stimulation and recording electrodes. Conf Proc IEEE Eng Med Biol Soc, 6: p. 4153–6.
Cogan SF, Troyk PR, Ehrlich J, et al. (2006), Potential-biased, asymmetric waveforms for charge-injection with activated iridium oxide (AIROF) neural stimulation electrodes. IEEE Trans Biomed Eng, 53(2): p. 327–32.
Conway BE (1991), Transition from ‘supercapacitor’ to ‘battery’ behavior in electrochemical energy storage. J Electrochem Soc, 138: p. 1539–48.
Dobelle WH (2000), Artificial vision for the blind by connecting a television camera to the visual cortex. ASAIO J, 46(1): p. 3–9.
Dobelle WH, Mladejovsky MG (1974), Phosphenes produced by electrical stimulation of human occipital cortex, and their application to the development of a prosthesis for the blind. J Physiol, 243(2): p. 553–76.
Dobelle WH, Mladejovsky MG, Evans JR, et al. (1976), “Braille” reading by a blind volunteer by visual cortex stimulation. Nature, 259(5539): p. 111–2.
Donaldson ND, Donaldson PE (1986), When are actively balanced biphasic (‘Lilly’) stimulating pulses necessary in a neurological prosthesis? I. Historical background; Pt resting potential; Q studies. Med Biol Eng Comput, 24(1): p. 41–9.
Donaldson ND, Donaldson PE (1986), When are actively balanced biphasic (‘Lilly’) stimulating pulses necessary in a neurological prosthesis? II. pH changes; noxious products; electrode corrosion; discussion. Med Biol Eng Comput, 24(1): p. 50–6.
Gottesfeld S, McIntyre JDE (1979), Electrochromism in anodic iridium oxide films II. pH effects on corrosion stability and the mechanisms of coloration and bleaching. J Electrochem Soc, 126: p. 742–50.
Gualtierotti T, Bailey P (1968), A neutral buoyancy micro-electrode for prolonged recording from single nerve units. Electroencephalogr Clin Neurophysiol, 25(1): p. 77–81.
Guyton DL, Hambrecht FT (1974), Theory and design of capacitor electrodes for chronic stimulation. Med Biol Eng, 12(5): p. 613–20.
Hu Z, Troyk PR, Brawn TP, et al. (2006), In vitro and in vivo charge capacity of AIROF microelectrodes. Conf Proc IEEE Eng Med Biol Soc, 1: p. 886–9.
Klein JD, Clauson SL, Cogan SF (1989), Morphology and charge capacity of sputtered iridium oxide films. J Vac Sci Technol, A7: p. 3043–7.
Ludwig KA, Uram JD, Yang J, et al. (2006), Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film. J Neural Eng, 3(1): p. 59–70.
McCreery DB, Agnew WF, Bullara LA (2002), The effects of prolonged intracortical microstimulation on the excitability of pyramidal tract neurons in the cat. Ann Biomed Eng, 30(1): p. 107–19.
McCreery D, Pikov V, Troyk PR (2010), Neuronal loss due to prolonged controlled-current stimulation with chronically implanted microelectrodes in the cat cerebral cortex. J Neural Eng, 7(3): p. 036005.
Nyberg T, Shimada A, Torimitsu K (2007), Ion conducting polymer microelectrodes for interfacing with neural networks. J Neurosci Methods, 160(1): p. 16–25.
Pickup PG, Birss VI (1987), A model for anodic hydrous oxide growth at iridium. J Electroanal Chem, 220: p. 83–100.
Richardson-Burns SM, Hendricks JL, Foster B, et al. (2007), Polymerization of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) around living neural cells. Biomaterials, 28(8): p. 1539–52.
Richardson-Burns SM, Hendricks JL, Martin DC (2007), Electrochemical polymerization of conducting polymers in living neural tissue. J Neural Eng, 4(2): p. L6–13.
Robblee LS, Lefko JL, Brummer SB (1983), Activated Ir: An electrode suitable for reversible charge injection in saline. J Electrochem Soc, 130: p. 731.
Robblee LS, McHardy J, Agnew WF, Bullara LA (1983), Electrical stimulation with Pt electrodes. VII. Dissolution of Pt electrodes during electrical stimulation of the cat cerebral cortex. J Neurosci Methods, 9(4): p. 301–8.
Robblee LS, Rose TL (1990), Electrochemical guidelines for selection of protocols and electrode materials for neural stimulation, in Neural Prostheses: Fundamental Studies, Agnew WF, McCreery DB, Editors. Prentice Hall: Englewood Cliffs, NJ. p. 25–66.
Rose TL, Kelliher EM, Robblee LS (1985), Assessment of capacitor electrodes for intracortical neural stimulation. J Neurosci Methods, 12(3): p. 181–93.
Salcman M, Bak MJ (1976), A new chronic recording intracortical microelectrode. Med Biol Eng, 14(1): p. 42–50.
Schmidt EM, Bak MJ, Hambrecht FT, et al. (1996), Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain, 119: p. 507–22.
Slavcheva E, Vitushinsky R, Mokwa W, Schnakenberg U (2004), Sputtered iridium oxide films as charge injection material for functional electrostimulation. J Electrochem Soc, 151(7): p. E226–37.
Wang K, Fishman HA, Dai H, Harris JS (2006), Neural stimulation with a carbon nanotube microelectrode array. Nano Lett, 6(9): p. 2043–8.
Wessling B, Mokwa W, Schnakenberg U (2006), RF-sputtering of iridium oxide to be used as stimulation material in functional medical implants. J Micromech Microeng, 16(6): p. S142–8.
Wise KD, Angell JB, Starr A (1970), An integrated-circuit approach to extracellular microelectrodes. IEEE Trans Biomed Eng, 17(3): p. 238–47.
Woods R (1974), Hydrogen adsorption on platinum, iridium and rhodium electrodes at reduced temperatures and determination of real surface area. J Electroanal Chem, 49(2): p. 217–26.
Xiao Y, Cui X, Hancock JM, et al. (2004), Electrochemical polymerization of poly(hydroxymethylated-3,4-ethylenedioxythiophene) (PEDOT-MeOH) on multichannel neural probes. Sens Actuators B, 99: p. 437–43.
Ziaie B, Nardin MD, Coghlan AR, Najafi K (1997), A single-channel implantable microstimulator for functional neuromuscular stimulation. IEEE Trans Biomed Eng, 44(10): p. 909–20.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Troyk, P.R. (2011). Biophysics/ Engineering of Cortical Electrodes. In: Dagnelie, G. (eds) Visual Prosthetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0754-7_11
Download citation
DOI: https://doi.org/10.1007/978-1-4419-0754-7_11
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-0753-0
Online ISBN: 978-1-4419-0754-7
eBook Packages: EngineeringEngineering (R0)