Abstract
In recent years, there has been a significant effort to restore heart function by the addition of stem cells directly into the myocardium. These cells are normally carried in a synthetic extracellular matrix and implanted into the injured heart. While there has been little demonstration of actual tissue regeneration using such methods, there has been long-term improvement from these techniques, and surprisingly, from the implantation of biomaterials alone, without any included cells. This has in fact led to therapies that directly add passive materials into the ventricle to help prevent heart failure. Therefore, theoretically evaluating the addition of passive material volumes into the myocardium is of clinical importance to understand the mechanisms for the improvement of ventricular mechanics and for optimizing such treatments. In this chapter we discuss the role of finite element studies in investigating the direct addition of non-contractile materials into the myocardium.
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American Heart Association. Heart and Stroke Statistical Update, 2008
Yu J, Christman KL, Chin E, Sievers RE, Saeed M, Lee RJ. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2009 Jan;137(1):180–7.
Kofidis T, Lebl DR, Martinez EC, Hoyt G, Tanaka M, Robbins RC. Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation. 2005;112:I173.
Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep–Oct;48(5):508–13.
Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation. 2006 Dec 12;114(24):2627–35. E-pub 2006 Nov 27.
Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005;289:H692.
Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech. 1995 Oct;28(10):1167–77.
Wall ST, Wenk JF, Peterson RC, Helgerson SL, Sabah HN, Ratcliffe MB, Guccione JM. Implantation of polymeric material into the globally failing left ventricle reduces pathologic myofiber stress – a finite element model simulation. Ann Biomed Eng. (submitted).
Sabbah HN, Shimoyama H, Kono T, Gupta RC, Sharov VG, Scicli G, Levine TB, Goldstein S. Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction. Circulation. 1994;89(6), 2852–9.
Streeter DD Jr, Spotnitz HM, Patel DP, Ross J Jr, Sonnenblick EH. Fiber orientation in the canine left ventricle during diastole and systole. Circ Res. 1969 Mar;24(3):339–47.
Wenk JF, Wall ST, Peterson RC, Helgerson SL, Sabah HN, Burger M, Stander N, Ratcliffe MB, Guccione JM. A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns. J. Biomech. Eng. accepted manuscript, doi:10.1115/1.4000165
Stander N, Roux W, Eggleston T, Craig K. LS-OPT user’s manual version 3.2. Livermore, CA: Livermore Software Technology Corporation, 2007.
Acknowledgments
The initial research was supported by National Institutes of Health grant 5R01 HL077921 (Dr. Guccione). We want to thank CardioPolymers, Inc. for providing additional funding for this research (Drs. Guccione, Wall and Wenk).
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Wall, S.T., Wenk, J.F., Jhun, CS., Guccione, J.M. (2010). Left Ventricular Implantation of Biomaterials. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_14
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DOI: https://doi.org/10.1007/978-1-4419-0730-1_14
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