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Passive Left Ventricular Constraint Devices

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Computational Cardiovascular Mechanics

Abstract

Both myocardial infarction and volume overloading associated with regurgitant valve lesions lead to eccentric left ventricular (LV) hypertrophy. The mechanism is presumed to be positive feedback between diastolic LV wall stress and eccentric LV hypertrophy. Further, in each case, an increase in LV size is an important adverse prognostic finding. The experience with skeletal muscle cardiomyoplasty led to the hypothesis that passive constraint of LV enlargement would interrupt the diastolic stress and eccentric hypertrophy cycle, in addition to halting and possibly reversing the adverse LV remodeling. A number of passive constraint devices such as the Acorn CorCap™ Cardiac Support Device (CSD), Paracor Medical HeartNet™ Ventricular Support System (VSS), and Myocor™ yosplint® have been used. Most recently, an Adjustable Fluid Filled Balloon CSD was proposed by Ghanta and colleagues. In this chapter we model the effect of passive constraint devices, with the exception of the Paracor Medical HeartNet™ VSS, on the LV stroke volume/end-diastolic pressure (Starling) relationship and regional distributions of stress in the local muscle fiber direction.

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Acknowledgments

This research was supported by National Institutes of Health grant 5R01 HL077921 (Dr. Guccione) and 5R01 HL063348 (Dr. Ratcliffe). We thank Ms. Kimberly S. Yan, a technical writing expert for proof-reading of this chapter.

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Authors and Affiliations

  1. Department of Surgery, University of California at San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA

    Choon-Sik Jhun, Kay Sun, E. Elaine Tseng, Mark B. Ratcliffe & Julius M. Guccione

  2. Department of Mechanical Engineering, Indian Institute of Science, Bangalore, India

    Namrata Gundiah

  3. Henry Ford Hospital, Detroit, MI, USA

    Hani N. Sabbah

Authors
  1. Choon-Sik Jhun
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  2. Namrata Gundiah
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  3. Kay Sun
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  4. Hani N. Sabbah
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  5. E. Elaine Tseng
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  6. Mark B. Ratcliffe
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  7. Julius M. Guccione
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Correspondence to Julius M. Guccione .

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Editors and Affiliations

  1. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Julius M. Guccione

  2. Purdue University Indianapolis, Indiana University, Barnhill Drive 635, Indianapolis, 46202, U.S.A.

    Ghassan S. Kassab

  3. Veterans Affairs Medical Center, University of California, San Francisco, Clement St. 4150, San Francisco, 94121, U.S.A.

    Mark B. Ratcliffe

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Jhun, CS. et al. (2010). Passive Left Ventricular Constraint Devices. In: Guccione, J., Kassab, G., Ratcliffe, M. (eds) Computational Cardiovascular Mechanics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0730-1_13

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  • DOI: https://doi.org/10.1007/978-1-4419-0730-1_13

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0729-5

  • Online ISBN: 978-1-4419-0730-1

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