TEPIDAS: A DAS Server for Integrating T-Cell Epitope Annotations
Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis software are available through the World Wide Web for the benefit of the research community. However, immunoinformatics developments have sometimes remained isolated from mainstream bioinformatics. Therefore, there is clearly a need for integration, which will empower the exchange of data and annotations within the scientific community in a quick and efficient fashion. In this chapter, we show how this can be achieved in a very simply manner by describing the TEPIDAS server, a DAS Annotation Server of HLA I-restricted CD8 T-cell epitopes specific of human pathogenic organisms.
KeywordsRestriction Element Distribute Annotation System Annotation Server Reference Server Efficient Fashion
Cumulative phenotypic frequency
Distributed annotation system
- HLA I
Human leukocyte antigen class I
Position-specific scoring matrix
We would like to thank Alfonso Valencia, Osvaldo Graña, and Jaime Fernandez Vera from the Spanish National Cancer Research Center (CNIO) for their helpful advice on DAS and ProServer. Work and authors were supported by grant SAF2006-07879 from the “Ministerio de Educación y Ciencia” of Spain, granted to PR.