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TEPIDAS: A DAS Server for Integrating T-Cell Epitope Annotations

  • M. García-Boronat
  • C. M. Díez-Rivero
  • Pedro Reche
Chapter
Part of the Immunomics Reviews: book series (IMMUN, volume 3)

Abstract

Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis software are available through the World Wide Web for the benefit of the research community. However, immunoinformatics developments have sometimes remained isolated from mainstream bioinformatics. Therefore, there is clearly a need for integration, which will empower the exchange of data and annotations within the scientific community in a quick and efficient fashion. In this chapter, we show how this can be achieved in a very simply manner by describing the TEPIDAS server, a DAS Annotation Server of HLA I-restricted CD8 T-cell epitopes specific of human pathogenic organisms.

Keywords

Restriction Element Distribute Annotation System Annotation Server Reference Server Efficient Fashion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CMV

Cumulative phenotypic frequency

DAS

Distributed annotation system

HLA I

Human leukocyte antigen class I

PSSM

Position-specific scoring matrix

Notes

Acknowledgments

We would like to thank Alfonso Valencia, Osvaldo Graña, and Jaime Fernandez Vera from the Spanish National Cancer Research Center (CNIO) for their helpful advice on DAS and ProServer. Work and authors were supported by grant SAF2006-07879 from the “Ministerio de Educación y Ciencia” of Spain, granted to PR.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • M. García-Boronat
  • C. M. Díez-Rivero
  • Pedro Reche
    • 1
  1. 1.Facultad de Medicina, Departamento de Immunología (Microbiología I)Universidad Complutense de MadridMadridSpain

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