The Immuno Polymorphism Database
The Immuno Polymorphism Database (IPD) (http://www.ebi.ac.uk/ipd/) is a set of specialist databases developed for the study of polymorphic genes of the immune system. The Database includes both information on allelic sequences of various genes and a cell bank of immunologically characterised melanoma cell lines. The sequence databases are developed in collaboration with specialist groups and nomenclature committees who provide and curate individual sections before they are submitted to IPD for online publication. These databases include: IPD-KIR, which contains the allelic sequences of Killer-cell Immunoglobulin-like Receptors; IPD-MHC, a database of sequences of the major histocompatibility complex of different species; and IPD-HPA, alloantigens expressed only on platelet. The IPD-ESTAB section of the project provides access to the European Searchable Tumour Cell-Line Database (ESTDAB), a cell bank of immunologically characterised melanoma cell lines.
KeywordsMajor Histocompatibility Complex Single Nucleotide Polymorphism Cell Bank Nomenclature Committee European Molecular Biology Laboratory
We would like to thank Peter Parham, Libby Guethlein, Christian Garcia and Chrissy Roberts for their work on IPD-KIR; our IPD-MHC collaborators Shirley Ellis, Lorna Kennedy, Ronald Bontrop, Natasja de Groot, Lutz Walter, Douglas Smith, Keith Ballingall, Mike Stear and René Stet; Nick Watkins and Paul Metcalfe for IPD-HPA and Graham Pawelec for ESTDAB. Our thanks also go to Matthew Waller and Sylvie Fail for their work on the tools and processing of submissions for the various databases and finally Peter Stoehr at the EBI for assisting in the continued collaboration between our group and the EBI.
- Cochrane G, Akhtar R, Aldebert P, Althorpe N, Baldwin A, Bates K, Bhattacharyya S, Bonfield J, Bower L, Browne P, Castro M, Cox T, Demiralp F, Eberhardt R, Faruque N, Hoad G, Jang M, Kulikova T, Labarga A, Leinonen R, Leonard S, Lin Q, Lopez R, Lorenc D, McWilliam H, Mukherjee G, Nardone F, Plaister S, Robinson S, Sobhany S, Vaughan R, Wu D, Zhu W, Apweiler R, Hubbard T, Birney E (2008) Priorities for nucleotide trace sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database. Nucleic Acids Res 36:D5–D12CrossRefPubMedGoogle Scholar
- Kennedy LJ, Altet L, Angles JM, Barnes A, Carter SD, Francino O, Gerlach JA, Happ GM, Ollier WE, Polvi A, Thomson W, Wagner JL (1999) Nomenclature for factors of the dog major histocompatibility system (DLA), 1998. First report of the ISAG DLA Nomenclature Committee. International Society for Animals Genetics. Tissue Antigens 54:312–321CrossRefPubMedGoogle Scholar
- Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, Cox S, Little AM, Alexander GJ, Cramp ME, O’Brien SJ, Rosenberg WM, Thomas DL, Carrington M (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305:872–874CrossRefPubMedGoogle Scholar
- Robinson J, Marsh SGE (2006) Immunoinformatics: predicting immunogenicity in silico. In: Flower D (ed) The IMGT/HLA Database. Humana, Totowa, pp 43–60Google Scholar
- Robinson J, Marsh SGE (2008) In: Davies MN, Ranganathan S, Flower DR (eds) Bioinformatics for immunomics, Springer, pp 33–45Google Scholar