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Collecting Duct Renin: A Critical Linkin Angiotensin II-Dependent Hypertension

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The Local Cardiac Renin-Angiotensin Aldosterone System

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Abstract

All of the components needed for angiotensin II generation are present within the renal tubular network of the kidney. This brief review is focused on recent evidence demonstrating that inappropriate activation of renin in distal nephron segments by acting on angiotensinogen generated in the proximal tubule cells and delivered to the distal nephron may contribute to increased distal intrarenal angiotensin II formation, sodium retention, and development and progression of hypertension. Moreover, mechanisms regulating collecting duct renin during Ang II-dependent hypertension are discussed.

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Acknowledgments

Research performed by the authors has been supported by grants from National Heart, Lung, and Blood Institute Grant HL-26731, National Institutes of Health Grant P20-RR-017659 from the Institutional Developmental Award (IdeA) program of NCRR, Eunice Kennedy Shriver National Institute of Child Health & Human Development Grant K12HD043451, and the Louisiana Board of Regents Millennium Health Excellence Fund (2001-06-07).

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Authors and Affiliations

  1. Department of Physiology, Tulane University Health Sciences Center, 70112, New Orleans, LA, USA

    Minolfa C. Prieto & L. Gabriel Navar

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  1. Minolfa C. Prieto
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  2. L. Gabriel Navar
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Editors and Affiliations

  1. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Edward D. Frohlich

  2. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Richard N. Re

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Prieto, M.C., Navar, L.G. (2009). Collecting Duct Renin: A Critical Linkin Angiotensin II-Dependent Hypertension. In: Frohlich, E., Re, R. (eds) The Local Cardiac Renin-Angiotensin Aldosterone System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0528-4_13

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  • DOI: https://doi.org/10.1007/978-1-4419-0528-4_13

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  • Online ISBN: 978-1-4419-0528-4

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