Abstract
Mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancers as well as other cancers [1,2]. Several studies have estimated the breast and ovarian cancer risks associated with BRCA1 and BRCA2 mutations [3–11]. Initial studies, based on families with multiple affected individuals, estimated that the risk of breast cancer by age 70 is 85% in BRCA1 and 84% in BRCA2 mutation carriers
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
BCLC. (1999). J Natl Cancer Inst, 91, 1310–6.
Thompson D and Easton DF. (2002). J Natl Cancer Inst, 94, 1358–65.
Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG and Easton DF. (2003). Am J Hum Genet, 72, 1117–30.
Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C and Bernstein JL. (2008). JAMA, 299, 194–201.
Easton DF, Ford D and Bishop DT. (1995). Am J Hum Genet, 56, 265–71.
Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare MD, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Ponder BA, Gayther SA, Zelada-Hedman M, et al. (1998). Am J Hum Genet, 62, 676–89.
Hopper JL, Southey MC, Dite GS, Jolley DJ, Giles GG, McCredie MR, Easton DF and Venter DJ. (1999). Cancer Epidemiol Biomarkers Prev, 8, 741–7.
Milne R, Osorio A, Ramon y Cajal T, Vega A, Llort G, de la Hoya M, Diez O, Alonso M, Lazaro C, Blanco I, Sanchez-de-Abajo A, Caldes T, Blano A, Grana G, Duran M, Velasco E, Chirivella I, Esteban Cardenosa E, Tejada M-I, EBeristain E, Miramar M-D, Calvo M-T, Martinex E, Guillen C, Salazar R, San Roman C, Antoniou A, Urioste M and Benitez J. (2008). Clin Cancer Res, 14, 2861–9.
Risch HA, McLaughlin JR, Cole DE, Rosen B, Bradley L, Kwan E, Jack E, Vesprini DJ, Kuperstein G, Abrahamson JL, Fan I, Wong B and Narod SA. (2001). Am J Hum Genet, 68, 700–710.
Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody LC and Tucker MA. (1997). N Engl J Med, 336, 1401–8.
Tryggvadottir L, Sigvaldason H, Olafsdottir GH, Jonasson JG, Jonsson T, Tulinius H and Eyfjord JE. (2006). J Natl Cancer Inst, 98, 116–22.
Simchoni S, Friedman E, Kaufman B, Gershoni-Baruch R, Orr-Urtreger A, Kedar-Barnes I, Shiri-Sverdlov R, Dagan E, Tsabari S, Shohat M, Catane R, King MC, Lahad A and Levy-Lahad E. (2006). Proc Natl Acad Sci USA, 103, 3770–4.
Boyd NF, Dite GS, Stone J, Gunasekara A, English DR, McCredie MR, Giles GG, Tritchler D, Chiarelli A, Yaffe MJ and Hopper JL. (2002). N Engl J Med, 347, 886–94.
Boyd NF, Rommens JM, Vogt K, Lee V, Hopper JL, Yaffe MJ and Paterson AD. (2005). Lancet Oncol, 6, 798–808.
Vachon CM, Sellers TA, Carlson EE, Cunningham JM, Hilker CA, Smalley RL, Schaid DJ, Kelemen LE, Couch FJ and Pankratz VS. (2007). Cancer Res, 67, 8412–8.
Mitchell G, Antoniou AC, Warren R, Peock S, Brown J, Davies R, Mattison J, Cook M, Warsi I, Evans DG, Eccles D, Douglas F, Paterson J, Hodgson S, Izatt L, Cole T, Burgess L, Eeles R and Easton DF. (2006). Cancer Res, 66, 1866–72.
Evans D, Smith A, Boyd M, Bulman M, Woodward E, Smith L, Moran A, Lalloo F and Maher E. (2005). Am J Hum Genet, Abstract 71.
Antoniou A, Cunningham A, Peto J, Evans D, Lalloo F, Narod S, Risch H, Eyfjord J, Hopper J, Southey M, Olsson H, Johannsson A, Borg A, Passini B, Radice P, Manoukian S, Eccles D, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tryggvadottir L, Syrjakoski K, Kallioniemi O-P, Eerola H, Nevanlinna H, Pharoah P and Easton D. (2008). Br J Cancer, 98, 1457–66.
Antoniou AC, Pharoah PD, McMullan G, Day NE, Stratton MR, Peto J, Ponder BJ and Easton DF. (2002). Br J Cancer, 86, 76–83.
Thompson D and Easton D. (2001). Am J Hum Genet, 68, 410–9.
Thompson D and Easton D. (2002). Cancer Epidemiol Biomarkers Prev, 11, 329–36.
Narod SA and Foulkes WD. (2004). Nat Rev Cancer, 4, 665–76.
Antoniou AC and Easton DF. (2006). Oncogene, 25, 5898–905.
Khoury MJ, Beaty TH and Liang KY. (1988). Am J Epidemiol, 127, 674–83.
Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L and Easton DF. (2002). J Clin Oncol, 20, 2310–8.
Pharoah PD, Antoniou A, Bobrow M, Zimmern RL, Easton DF and Ponder BA. (2002). Nat Genet, 31, 33–6.
Chenevix-Trench G, Milne RL, Antoniou AC, Couch FJ, Easton DF and Goldgar DE. (2007). Breast Cancer Res, 9, 104.
Giguere Y, Dewailly E, Brisson J, Ayotte P, Laflamme N, Demers A, Forest VI, Dodin S, Robert J and Rousseau F. (2001). Cancer Res, 61, 5869–74.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW and Hunter DJ. (2002). Cancer Res, 62, 1045–9.
Modugno F. (2004). Am J Epidemiol, 159, 319–35.
Spurdle AB, Antoniou AC, Duffy DL, Pandeya N, Kelemen L, Chen X, Peock S, Cook MR, Smith PL, Purdie DM, Newman B, Dite GS, Apicella C, Southey MC, Giles GG, Hopper JL, Chenevix-Trench G and Easton DF. (2005). Breast Cancer Res, 7, R176–83.
Suter NM, Malone KE, Daling JR, Doody DR and Ostrander EA. (2003). Cancer Epidemiol Biomarkers Prev, 12, 127–35.
Zeegers MP, Kiemeney LA, Nieder AM and Ostrer H. (2004). Cancer Epidemiol Biomarkers Prev, 13, 1765–71.
Rebbeck TR, Kantoff PW, Krithivas K, Neuhausen S, Blackwood MA, Godwin AK, Daly MB, Narod SA, Garber JE, Lynch HT, Weber BL and Brown M. (1999). Am J Hum Genet, 64, 1371–7.
Kadouri L, Easton DF, Edwards S, Hubert A, Kote-Jarai Z, Glaser B, Durocher F, Abeliovich D, Peretz T and Eeles RA. (2001). Br J Cancer, 85, 36–40.
Dagan E, Friedman E, Paperna T, Carmi N and Gershoni-Baruch R. (2002). Eur J Hum Genet, 10, 724–8.
Kim SC, Ju W, Mahavni V, Geisler JP and Buller RE. (2006). Int J Gynecol Cancer, 16 Suppl 1, 190–4.
Menin C, Banna GL, De Salvo G, Lazzarotto V, De Nicolo A, Agata S, Montagna M, Sordi G, Nicoletto O, Chieco-Bianchi L and D’Andrea E. (2001). Cancer Lett, 168, 31–6.
Irvine RA, Ma H, Yu MC, Ross RK, Stallcup MR and Coetzee GA. (2000). Hum Mol Genet, 9, 267–74.
Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Brunet JS, Vesprini D, Garber JE, Lynch HT, Weber BL and Brown M. (2001). Cancer Res, 61, 5420–4.
Colilla S, Kantoff PW, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Garber JE, Lynch HT, Brown M, Weber BL and Rebbeck TR. (2006). Carcinogenesis, 27, 599–605.
Kadouri L, Kote-Jarai Z, Easton DF, Hubert A, Hamoudi R, Glaser B, Abeliovich D, Peretz T and Eeles RA. (2004). Int J Cancer, 108, 399–403.
Hughes DJ, Ginolhac SM, Coupier I, Barjhoux L, Gaborieau V, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Uhrhammer N, Lasset C, Giraud S, Sobol H, Hardouin A, Berthet P, Peyrat JP, Fournier J, Nogues C, Lidereau R, Muller D, Fricker JP, Longy M, Toulas C, Guimbaud R, Yannoukakos D, Mazoyer S, Lynch HT, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D and Sinilnikova OM. (2005). Int J Cancer, 117, 230–3.
Spurdle AB, Antoniou AC, Kelemen L, Holland H, Peock S, Cook MR, Smith PL, Greene MH, Simard J, Plourde M, Southey MC, Godwin AK, Beck J, Miron A, Daly MB, Santella RM, Hopper JL, John EM, Andrulis IL, Durocher F, Struewing JP, Easton DF and Chenevix-Trench G. (2006). Cancer Epidemiol Biomarkers Prev, 15, 76–9.
Thomas M, Kalita A, Labrecque S, Pim D, Banks L and Matlashewski G. (1999). Mol Cell Biol, 19, 1092–100.
Wang-Gohrke S, Weikel W, Risch H, Vesprini D, Abrahamson J, Lerman C, Godwin A, Moslehi R, Olipade O, Brunet JS, Stickeler E, Kieback DG, Kreienberg R, Weber B, Narod SA and Runnebaum IB. (1999). Br J Cancer, 81, 179–83.
Osorio A, Martinez-Delgado B, Pollan M, Cuadros M, Urioste M, Torrenteras C, Melchor L, Diez O, De La Hoya M, Velasco E, Gonzalez-Sarmiento R, Caldes T, Alonso C and Benitez J. (2006). Hum Mutat, 27, 242–8.
Karran P. (2000). Curr Opin Genet Dev, 10, 144–50.
Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T and Livingston DM. (1997). Cell, 88, 265–75.
Wong AK, Pero R, Ormonde PA, Tavtigian SV and Bartel PL. (1997). J Biol Chem, 272, 31941–4.
Shu Z, Smith S, Wang L, Rice MC and Kmiec EB. (1999). Mol Cell Biol, 19, 8686–93.
Levy-Lahad E, Lahad A, Eisenberg S, Dagan E, Paperna T, Kasinetz L, Catane R, Kaufman B, Beller U, Renbaum P and Gershoni-Baruch R. (2001). Proc Natl Acad Sci USA, 98, 3232–6.
Wang WW, Spurdle AB, Kolachana P, Bove B, Modan B, Ebbers SM, Suthers G, Tucker MA, Kaufman DJ, Doody MM, Tarone RE, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel GH, Chenevix-Trench G, Offit K, Godwin AK and Struewing JP. (2001). Cancer Epidemiol Biomarkers Prev, 10, 955–60.
Kadouri L, Kote-Jarai Z, Hubert A, Durocher F, Abeliovich D, Glaser B, Hamburger T, Eeles RA and Peretz T. (2004). Br J Cancer, 90, 2002–5.
Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ and Hamann U. (2007). Cancer Epidemiol Biomarkers Prev, 16, 270–5.
Jakubowska A, Narod SA, Goldgar DE, Mierzejewski M, Masojc B, Nej K, Huzarska J, Byrski T, Gorski B and Lubinski J. (2003). Cancer Epidemiol Biomarkers Prev, 12, 457–9.
Gershoni-Baruch R, Dagan E, Israeli D, Kasinetz L, Kadouri E and Friedman E. (2000). Eur J Cancer, 36, 2313–6.
Pepe C, Guidugli L, Sensi E, Aretini P, D’Andrea E, Montagna M, Manoukian S, Ottini L, Radice P, Viel A, Bevilacqua G and Caligo MA. (2007). Breast Cancer Res Treat, 103, 29–36.
Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ and Hamann U. (2007). Breast Cancer Res Treat, 104, 299–308.
Phelan CM, Rebbeck TR, Weber BL, Devilee P, Ruttledge MH, Lynch HT, Lenoir GM, Stratton MR, Easton DF, Ponder BA, Cannon-Albright L, Larsson C, Goldgar DE and Narod SA. (1996). Nat Genet, 12, 309–11.
Weitzel JN, Ding S, Larson GP, Nelson RA, Goodman A, Grendys EC, Ball HG and Krontiris TG. (2000). Cancer Res, 60, 259–61.
Runnebaum IB, Wang-Gohrke S, Vesprini D, Kreienberg R, Lynch H, Moslehi R, Ghadirian P, Weber B, Godwin AK, Risch H, Garber J, Lerman C, Olopade OI, Foulkes WD, Karlan B, Warner E, Rosen B, Rebbeck T, Tonin P, Dube MP, Kieback DG and Narod SA. (2001). Pharmacogenetics, 11, 635–8.
Pearce CL, Hirschhorn JN, Wu AH, Burtt NP, Stram DO, Young S, Kolonel LN, Henderson BE, Altshuler D and Pike MC. (2005). J Natl Cancer Inst, 97, 51–9.
Ginolhac SM, Gad S, Corbex M, Bressac-De-Paillerets B, Chompret A, Bignon YJ, Peyrat JP, Fournier J, Lasset C, Giraud S, Muller D, Fricker JP, Hardouin A, Berthet P, Maugard C, Nogues C, Lidereau R, Longy M, Olschwang S, Toulas C, Guimbaud R, Yannoukakos D, Szabo C, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch HT, Goldgar D, Stoppa-Lyonnet D, Lenoir GM and Sinilnikova OM. (2003). Cancer Epidemiol Biomarkers Prev, 12, 90–5.
Hughes DJ, Ginolhac SM, Coupier I, Corbex M, Bressac-de-Paillerets B, Chompret A, Bignon YJ, Uhrhammer N, Lasset C, Giraud S, Hardouin A, Berthet P, Peyrat JP, Fournier J, Nogues C, Lidereau R, Muller D, Fricker JP, Longy M, Toulas C, Guimbaud R, Maugard C, Olschwang S, Yannoukakos D, Durocher F, Moisan AM, Simard J, Mazoyer S, Lynch HT, Szabo C, Lenoir GM, Goldgar DE, Stoppa-Lyonnet D and Sinilnikova OM. (2005). Cancer Epidemiol Biomarkers Prev, 14, 265–7.
Auranen A, Spurdle AB, Chen X, Lipscombe J, Purdie DM, Hopper JL, Green A, Healey CS, Redman K, Dunning AM, Pharoah PD, Easton DF, Ponder BA, Chenevix-Trench G and Novik KL. (2003). Int J Cancer, 103, 427–30.
Healey CS, Dunning AM, Teare MD, Chase D, Parker L, Burn J, Chang-Claude J, Mannermaa A, Kataja V, Huntsman DG, Pharoah PD, Luben RN, Easton DF and Ponder BA. (2000). Nat Genet, 26, 362–4.
Spurdle AB, Hopper JL, Chen X, Dite GS, Cui J, McCredie MR, Giles GG, Ellis-Steinborner S, Venter DJ, Newman B, Southey MC and Chenevix-Trench G. (2002). Cancer Epidemiol Biomarkers Prev, 11, 413–6.
The Breast Cancer Association Consortium. (2006). J Natl Cancer Inst 98, 1382–96.
Stacey SN, Sulem P, Johannsson OT, Helgason A, Gudmundsson J, Kostic JP, Kristjansson K, Jonsdottir T, Sigurdsson H, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Bergthorsson JT, Amundadottir LT, Gulcher JR, Thorsteinsdottir U, Kong A and Stefansson K. (2006). PLoS Med, 3, e217.
Vahteristo P, Syrjakoski K, Heikkinen T, Eerola H, Aittomaki K, von Smitten K, Holli K, Blomqvist C, Kallioniemi OP and Nevanlinna H. (2006). Eur J Hum Genet, 14, 167–72.
Jakubowska A, Gronwald J, Gorski B, Huzarski T, Byrski T, Benner A, Lubinski J, Scott RJ and Hamann U. (2007). Breast Cancer Res Treat, 104, 67–74.
Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ and Hamann U. (2007). J Med Genet, 44, 408–11.
Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, Edler L, Lubinski J, Scott RJ and Hamann U. (2007). Cancer Lett.
Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE and Minna JD. (2008). Cancer Res, 68, 22–5.
Nathanson KL, Shugart YY, Omaruddin R, Szabo C, Goldgar D, Rebbeck TR and Weber BL. (2002). Hum Mol Genet, 11, 1327–32.
Savelyeva L, Claas A, Gier S, Schlag P, Finke L, Mangion J, Stratton MR and Schwab M. (1998). Cancer Res, 58, 863–6.
Savelyeva L, Claas A, Matzner I, Schlag P, Hofmann W, Scherneck S, Weber B and Schwab M. (2001). Cancer Res, 61, 5179–85.
Antoniou AC, Sinilnikova OM, Simard J, Leone M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G, Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Gorski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, Spurdle AB, Chen X, Waddell N, Cloonan N, Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF and Chenevix-Trench G. (2007). Am J Hum Genet, 81, 1186–200.
Antoniou A, Spurdle AB, Similnikova OM, Healey S, Pooley KA, Schutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Hofmann W, Sutter C, Niederacher D, Deisler H, Caldes T, Kampjarvi K, Nevanlimna H, Simard J, Beesley J, Chen X, kConFab, Neuhausen SL, Rebbeck TR, Wagner T, Lynch HT, Isaacs C, Weitzel J, Ganz PA, Daly MB, Tomlinson G, Olopade OI, Blum JL, Couch FJ, Peterlongo P, Manoukian S, Barile M, Radice P, Szabo CI, Pereira LHM, Greene MH, Rennert G, Lejbkowicz F, Barnett-Griness O, Andrulis I, Ozcelik H, OCGN, Gerdes A-M, Caligo MA, Laitman Y, Kaufmann B, Milgrom R, Friedman E, SWE-BRCA, Domchek SM, Nathanson KL, Osorio A, Llort G, Milne RL, Benitez J, Hamann U, Hogervorst FBL, M.A.R, Manders P, Ligtenberg MLJ, van den Ouweland AMW, Peock S, Cook M, Platte R, Evans DG, Eeles R, Pichert G, Chu G, Eccles D, Davidson R, Douglas F, EMBRACE, Godwin AK, Barjhoux L, Mazoyer S, Sobol H, Bourdon V, Eisinger F, Chompret A, Capoulade C, Bressac-de-Paillerets B, Lenoir GM, Gauthier-Villars M, Houdayer C, Stoppa-Lyonnet D, Chenevix-Trench G and Easton DF, CIMBA. (2008). Am J Hum Genet, 82, 937–48.
Zuker M. (2003). Nucleic Acids Res, 31, 3406–15.
Davuluri RV, Suzuki Y, Sugano S and Zhang MQ. (2000). Genome Res, 10, 1807–16.
Hughes TA. (2006). Trends Genet, 22, 119–22.
Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM, Day NE, Easton DF, Ponder BA, Pharoah PD and Dunning A. (2002). Hum Mol Genet, 11, 1399–407.
Webb PM, Hopper JL, Newman B, Chen X, Kelemen L, Giles GG, Southey MC, Chenevix-Trench G and Spurdle AB. (2005). Cancer Epidemiol Biomarkers Prev, 14, 319–23.
Bodvarsdottir SK, Hilmarsdottir H, Birgisdottir V, Steinarsdottir M, Jonasson JG and Eyfjord JE. (2007). Cancer Lett, 248, 96–102.
Cox DG, Hankinson SE and Hunter DJ. (2006). Cancer Causes Control, 17, 81–3.
Dai Q, Cai QY, Shu XO, Ewart-Toland A, Wen WQ, Balmain A, Gao YT and Zheng W. (2004). Cancer Epidemiol Biomarkers Prev, 13, 2065–70.
Fletcher O, Johnson N, Palles C, dos Santos Silva I, McCormack V, Whittaker J, Ashworth A and Peto J. (2006). J Natl Cancer Inst, 98, 1014–8.
Couch FJ, Sinilnikova O, Vierkant RA, Pankratz VS, Fredericksen ZS, Stoppa-Lyonnet D, Coupier I, Hughes D, Hardouin A, Berthet P, Peock S, Cook M, Baynes C, Hodgson S, Morrison PJ, Porteous ME, Jakubowska A, Lubinski J, Gronwald J, Spurdle AB, Schmutzler R, Versmold B, Engel C, Meindl A, Sutter C, Horst J, Schaefer D, Offit K, Kirchhoff T, Andrulis IL, Ilyushik E, Glendon G, Devilee P, Vreeswijk MP, Vasen HF, Borg A, Backenhorn K, Struewing JP, Greene MH, Neuhausen SL, Rebbeck TR, Nathanson K, Domchek S, Wagner T, Garber JE, Szabo C, Zikan M, Foretova L, Olson JE, Sellers TA, Lindor N, Nevanlinna H, Tommiska J, Aittomaki K, Hamann U, Rashid MU, Torres D, Simard J, Durocher F, Guenard F, Lynch HT, Isaacs C, Weitzel J, Olopade OI, Narod S, Daly MB, Godwin AK, Tomlinson G, Easton DF, Chenevix-Trench G and Antoniou AC. (2007). Cancer Epidemiol Biomarkers Prev, 16, 1416–21.
Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schurmann P, Dork T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, et al. (2007). Nature, 447, 1087–93.
Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Jr., Hoover RN, Thomas G and Chanock SJ. (2007). Nat Genet, 39, 870–4.
Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, Masson G, Jakobsdottir M, Thorlacius S, Helgason A, Aben KK, Strobbe LJ, Albers-Akkers MT, Swinkels DW, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Godino J, Garcia-Prats MD, Polo E, Tres A, Mouy M, Saemundsdottir J, Backman VM, Gudmundsson L, Kristjansson K, Bergthorsson JT, Kostic J, Frigge ML, Geller F, Gudbjartsson D, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Jonsson T, von Holst S, Werelius B, Margolin S, Lindblom A, Mayordomo JI, Haiman CA, Kiemeney LA, Johannsson OT, Gulcher JR, Thorsteinsdottir U, Kong A and Stefansson K. (2007). Nat Genet, 39, 865–9.
Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, Richesson D, Bojesen SE, Nordestgaard BG, Axelsson CK, Arias JI, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Zamora P, Brauch H, Justenhoven C, Hamann U, Ko Y-D, Bruening T, Haas S, Dork T, Schurmann P, Hillemanns P, Borddanova N, Bremer M, Karstens JH, Fagerholm R, Aaltonen K, Aittomaki K, von Smitte K, Blomqvist C, Mannermaa A, Uusitupa M, Eskelinin M, Tengstrom M, Kosma V-M, Kataja V, Chenevix-Trench G, Spurdle AB, Beesley J, Chen X, Group AOCS, Cancer TKCFfRiFB, Devilee P, van Asperen C, Jacobi CE, Tollenaar RAEM, Huijts P, Klign J, Chang-Claude J, Kropp S, Slanger T, Flesch-Janys D, Mutschelknauss E, Salazar R, Wang-Gohrke S, Couch F, Goode E, Olsen JE, Vachon C, Frederiicksen ZS, Giles GG, Baglietto S, Severi G, Hopper JL, English DR, Southey MC, Haiman C, Henderson BE, Kolonel LN, Le Marchand L, Stram DO, Hunter DJ, Handkinson SE, Cox DG, Tamini R, Kraft P, Sherman M, Chanock S, Lissowska J, Brinton L, Peplonska B, Klijn J, Hooning M, Meigjers-Heijboer H, Collee JM, van den Ouweland A, Uitterlinden A, Liu J, Lin LY, Yuqing L, Humphreys K, Czene K, Cox A, Balasubramanian SP, Cross SS, Reed MWR, Blows F, Driver K, et al. (2008). PLOS Genet, 4, e1000054.
Lakhani SR, Reis-Filho JS, Fulford L, Penault-Llorca F, van der Vijver M, Parry S, Bishop T, Benitez J, Rivas C, Bignon YJ, Chang-Claude J, Hamann U, Cornelisse CJ, Devilee P, Beckmann MW, Nestle-Kramling C, Daly PA, Haites N, Varley J, Lalloo F, Evans G, Maugard C, Meijers-Heijboer H, Klijn JG, Olah E, Gusterson BA, Pilotti S, Radice P, Scherneck S, Sobol H, Jacquemier J, Wagner T, Peto J, Stratton MR, McGuffog L and Easton DF. (2005). Clin Cancer Res, 11, 5175–80.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Chenevix-Trench, G., Antoniou, A.C. (2009). Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers. In: Welcsh, P. (eds) The Role of Genetics in Breast and Reproductive Cancers. Cancer Genetics. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0477-5_6
Download citation
DOI: https://doi.org/10.1007/978-1-4419-0477-5_6
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-0476-8
Online ISBN: 978-1-4419-0477-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)