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Applications of MRI to Psychopharmacology

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Functional Neuroradiology

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Abstract

Pharmacological functional magnetic resonance (pharmacoMRI or phMRI) refers to the use of functional magnetic resonance imaging (fMRI) after administration of a psychotropic agent [1], but can be defined more broadly as the application of MRI methods to basic and clinical psychopharmacology questions. There has been significant growth in this field over the past decade, with a steady increase in published papers, perhaps attesting to the significant potential of phMRI for advancing psychopharmacological knowledge in important ways [2–9]. In this chapter, we begin by outlining some general issues in phMRI, outlining some of its advantages and limitations. We then go on to illustrate the potential value of phMRI by discussing both animal and clinical work.

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Acknowledgments

This work was supported in part by NIH/NIDA.

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Authors and Affiliations

  1. Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital (J-2), Anzio Road, Observatory, 7925, Cape Town, South Africa

    Dan J. Stein MD, PhD (Professor and Chair)

  2. FMRI Section, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, 251 Bayview Boulevard, Suite 200, Room 07A709, Baltimore, MD, 21224, USA

    Yihong Yang PhD (Chief)

  3. Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, 251 Bayview Boulevard, Suite 200, Room 07A717, Baltimore, MD, 21224, USA

    Betty Jo Salmeron MD (Staff Clinician)

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  1. Dan J. Stein MD, PhD
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  1. Temple University School of Medicine, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Scott H. Faro

  2. Dept. of Radiology, Temple University Hospital, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Feroze B. Mohamed

  3. , Radiology, University of Southern California School, Zonal Avenue 1975, Los Angeles, 90033, California, USA

    Meng Law

  4. , Department of Radiology, Medical College of Wisconsin, Watertown Plank Road 8701, Milwaukee, 53226, USA

    John T. Ulmer

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Stein, D.J., Yang, Y., Salmeron, B.J. (2011). Applications of MRI to Psychopharmacology. In: Faro, S., Mohamed, F., Law, M., Ulmer, J. (eds) Functional Neuroradiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0345-7_33

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