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Physical Principles of MR Perfusion and Permeability Imaging: Gadolinium Bolus Technique

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Functional Neuroradiology

Abstract

The use of dynamic contrast agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable during static conventional contrast-enhanced MR techniques. These additional data may allow further refinement of differential diagnoses focusing on interpretation in terms of microvascular physiology. The dominant dynamic gadolinium (Gd)-enhanced bolus injection MR techniques currently utilized in brain imaging are (1) T1-weighted dynamic contrast-enhanced (DCE) and (2) T2/T2*-weighted dynamic susceptibility contrast (DSC) imaging. This chapter will provide an overview of general physical principles of these techniques.

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Author information

Authors and Affiliations

  1. Division of Neuroradiology, Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo Street, Second Floor Imaging, Los Angeles, CA, 90033, USA

    Mark S. Shiroishi MD (Assistant Professor)

  2. Department of Radiology, Beneficencia Portuguesa de Sao Paulo, Rua Maestro Cardim, 769, Il Subsolo, Paraiso, Sao Paulo, SP, 01323–000, Brazil

    Saulo Lacerda MD

  3. Department of Radiology, Shekou People Hospital, No. 7 Industry Road, Shekou, Nanshan, Shenzhen, Guangdong, 518067, China

    Xiaoli Tang MD (Professor)

  4. Research and Development, iCAD, Inc., 98 Spit Brook Rd, #100, Nashua, NH, 03062, USA

    Naira Muradyan PhD (Lead Senior Research Scientist)

  5. Department of Radiology, Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood Building, Suite 2115, Philadelphia, PA, 19104, USA

    Timothy P. L. Roberts PhD (Professor, Oberkircher Family Chair in Pediatric Radiology)

  6. Los Angeles County Hospital and USC Medical Center, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, HCC II, Suite L 1600, Los Angeles, CA, 90033, USA

    Meng Law MD (Professor of Radiology and Neurosurgery, Director of Neuroradiology)

Authors
  1. Mark S. Shiroishi MD
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  2. Saulo Lacerda MD
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  3. Xiaoli Tang MD
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  4. Naira Muradyan PhD
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  5. Timothy P. L. Roberts PhD
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  6. Meng Law MD
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Corresponding author

Correspondence to Mark S. Shiroishi MD .

Editor information

Editors and Affiliations

  1. Temple University School of Medicine, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Scott H. Faro

  2. Dept. of Radiology, Temple University Hospital, 3401 Broad Street, Philadelphia, 19140-5189, Pennsylvania, USA

    Feroze B. Mohamed

  3. , Radiology, University of Southern California School, Zonal Avenue 1975, Los Angeles, 90033, California, USA

    Meng Law

  4. , Department of Radiology, Medical College of Wisconsin, Watertown Plank Road 8701, Milwaukee, 53226, USA

    John T. Ulmer

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Shiroishi, M.S., Lacerda, S., Tang, X., Muradyan, N., Roberts, T.P.L., Law, M. (2011). Physical Principles of MR Perfusion and Permeability Imaging: Gadolinium Bolus Technique. In: Faro, S., Mohamed, F., Law, M., Ulmer, J. (eds) Functional Neuroradiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0345-7_3

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  • DOI: https://doi.org/10.1007/978-1-4419-0345-7_3

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0343-3

  • Online ISBN: 978-1-4419-0345-7

  • eBook Packages: MedicineMedicine (R0)

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