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The Basal Ganglia IX pp 387–397Cite as

Changes in the Subcellular Localization and Functions of GABA-B Receptors in the Globus Pallidus of MPTP-Treated Monkeys

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 58))

Abstract

We have analyzed whether the subcellular location of GABA-B receptors and the electrophysiologic effects of local administration of GABA-B receptor ligands in the external and internal segments of the globus pallidus (GPe and GPi, respectively) in monkeys change with the induction of parkinsonism. Rhesus monkeys were rendered parkinsonian by treatment with MPTP. Electron microscopy immunoperoxidase for GABA-B R1 was performed in GPe and GPi. Compared with normal monkeys, the overall density of GABA-B R1-immunoreactive dendrites remained the same, but the density of immunolabeled axons increased significantly in both pallidal segments of MPTP-treated monkeys. Single unit recordings in awake monkeys showed that blockade of GABA-B receptors did not consistently affect the activity of GPe or GPi. However, in all neurons tested, application of a GABA-B agonist inhibited the firing rate. These results suggest that dopamine depletion induces an increased presynaptic expression of GABA-B receptors in both pallidal segments, perhaps facilitating a more prominent role of GABA-B-mediated presynaptic regulation of neurotransmitter release in the pallidum.

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Authors and Affiliations

  1. Yerkes Research Center, 954 Gatewood Road NE, Atlanta, GA, 30329, USA

    Adriana Galvan, Xing Hu, Yoland Smith & Thomas Wichmann

  2. Hindustan Institute of Medical Sciences and Research, Knowledge Park-III, Greater Noida, Up, 201306, India

    Bijli Nanda

Authors
  1. Adriana Galvan
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  2. Bijli Nanda
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  3. Xing Hu
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  4. Yoland Smith
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  5. Thomas Wichmann
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Corresponding author

Correspondence to Adriana Galvan .

Editor information

Editors and Affiliations

  1. Dept. Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, 1007 MB, Netherlands

    Hendrik Jan Groenewegen

  2. Medical Center, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands

    Pieter Voorn

  3. Department of Neurology, Vrije Universiteit Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands

    Henk W. Berendse

  4. Medical Center, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands

    Antonius B. Mulder

  5. Medical Centre, Radboud University Nijmegen, Geert Grooteplein 21a, Nijmegen, 6525 EZ, Netherlands

    Alexander R. Cools

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Galvan, A., Nanda, B., Hu, X., Smith, Y., Wichmann, T. (2009). Changes in the Subcellular Localization and Functions of GABA-B Receptors in the Globus Pallidus of MPTP-Treated Monkeys. In: Groenewegen, H., Voorn, P., Berendse, H., Mulder, A., Cools, A. (eds) The Basal Ganglia IX. Advances in Behavioral Biology, vol 58. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0340-2_30

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  • DOI: https://doi.org/10.1007/978-1-4419-0340-2_30

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0339-6

  • Online ISBN: 978-1-4419-0340-2

  • eBook Packages: MedicineMedicine (R0)

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